The first H- 2 mutant workshop

Henry I. Kohn, Jan Klein, Roger W. Melvold, Stanley G. Nathenson, Donald Pious, Donald C. Shreffler

Research output: Contribution to journalArticlepeer-review

80 Scopus citations


The major accomplishment of the Workshop was probably the realization of many of its participants that most of the 21 available H- 2 variants are true mutations very likely derived from single nucleotide substitutions. Any theory of the pleiotropic effect of the H- 2 genes must now take this fact into account; such theories must also consider the observation that a wide variety of immunological phenomena are affected by H- 2 mutations and thus, apparently, are controlled by a single gene.

Original languageEnglish (US)
Pages (from-to)279-294
Number of pages16
Issue number1
StatePublished - Dec 1978

All Science Journal Classification (ASJC) codes

  • Immunology
  • Genetics


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