The first H- 2 mutant workshop

Henry I. Kohn; Jan Klein; Roger W. Melvold; Stanley G. Nathenson; Donald Pious; Donald C. Shreffler

doi:10.1007/BF01844019

The first H- 2 mutant workshop

Henry I. Kohn
, Jan Klein
, Roger W. Melvold
, Stanley G. Nathenson
, Donald Pious
, Donald C. Shreffler

Biology

Research output: Contribution to journal › Article › peer-review

80 Scopus citations

Abstract

The major accomplishment of the Workshop was probably the realization of many of its participants that most of the 21 available H- 2 variants are true mutations very likely derived from single nucleotide substitutions. Any theory of the pleiotropic effect of the H- 2 genes must now take this fact into account; such theories must also consider the observation that a wide variety of immunological phenomena are affected by H- 2 mutations and thus, apparently, are controlled by a single gene.

Original language	English (US)
Pages (from-to)	279-294
Number of pages	16
Journal	Immunogenetics
Volume	7
Issue number	1
DOIs	https://doi.org/10.1007/BF01844019
State	Published - Dec 1978

All Science Journal Classification (ASJC) codes

Immunology
Genetics

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10.1007/BF01844019

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title = "The first H- 2 mutant workshop",

abstract = "The major accomplishment of the Workshop was probably the realization of many of its participants that most of the 21 available H- 2 variants are true mutations very likely derived from single nucleotide substitutions. Any theory of the pleiotropic effect of the H- 2 genes must now take this fact into account; such theories must also consider the observation that a wide variety of immunological phenomena are affected by H- 2 mutations and thus, apparently, are controlled by a single gene.",

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AU - Kohn, Henry I.

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AU - Melvold, Roger W.

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AU - Pious, Donald

AU - Shreffler, Donald C.

PY - 1978/12

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N2 - The major accomplishment of the Workshop was probably the realization of many of its participants that most of the 21 available H- 2 variants are true mutations very likely derived from single nucleotide substitutions. Any theory of the pleiotropic effect of the H- 2 genes must now take this fact into account; such theories must also consider the observation that a wide variety of immunological phenomena are affected by H- 2 mutations and thus, apparently, are controlled by a single gene.

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The first H- 2 mutant workshop

Abstract

All Science Journal Classification (ASJC) codes

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