TY - JOUR
T1 - The formation of 2,3‐disubstituted thiazolidin‐4‐ones from s‐α'‐aminomercaptoacetic acid derivatives
AU - Tierney, John
PY - 1989
Y1 - 1989
N2 - Variously substituted N‐benzylidineanilines rapidly react with thioglycolic acid to generate S‐α'‐aminomercaptoacetic acid derivatives. The latter subsequently cyclize to the corresponding 2,3‐diarylthiazolidin‐4‐ones. Kinetics for the first order cyclization reaction in the solvents toluene, carbon tetrachloride and nitrobenzene have been obtained over the temperature range 333 K to 383 K and are in accord with a neutral, but geometrically complex transition state.
AB - Variously substituted N‐benzylidineanilines rapidly react with thioglycolic acid to generate S‐α'‐aminomercaptoacetic acid derivatives. The latter subsequently cyclize to the corresponding 2,3‐diarylthiazolidin‐4‐ones. Kinetics for the first order cyclization reaction in the solvents toluene, carbon tetrachloride and nitrobenzene have been obtained over the temperature range 333 K to 383 K and are in accord with a neutral, but geometrically complex transition state.
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U2 - 10.1002/jhet.5570260419
DO - 10.1002/jhet.5570260419
M3 - Article
AN - SCOPUS:84986525768
SN - 0022-152X
VL - 26
SP - 997
EP - 1001
JO - Journal of Heterocyclic Chemistry
JF - Journal of Heterocyclic Chemistry
IS - 4
ER -