Towards the elucidation of the cellular function(s) of GPα1, we have characterized its subcellular localization using immunofluorescence and cell fractionation. GPα1 is not present in nuclei or chloroplasts. It is a membrane-bound protein, and analysis of isolated endoplasmic and plasma membranes indicates a good correlation between GPα1 in both the plasma membrane and the ER compartment. Interestingly, these results may suggest more different functions for GPα1: it might be involved in transmission of extracellular signals across the plasma membrane and in the cytoplasm, and/or it may also be involved in regulating some aspects of the ER functions or membrane trafficking between both membranes.
All Science Journal Classification (ASJC) codes
- Structural Biology
- Molecular Biology
- Cell Biology