The genetic legacy of paleolithic Homo sapiens sapiens in extant europeans: A Y chromosome perspective

O. Semino; G. Passarino; P. J. Oefner; A. A. Lin; S. Arbuzova; L. E. Beckman; G. De Benedictis; P. Francalacci; A. Kouvatsi; S. Limborska; M. Marcikiae; A. Mika; B. Mika; D. Primorac; A. S. Santachiara-Benerecetti; L. L. Cavalli-Sforza; P. A. Underhill

doi:10.1126/science.290.5494.1155

The genetic legacy of paleolithic Homo sapiens sapiens in extant europeans: A Y chromosome perspective

O. Semino, G. Passarino, P. J. Oefner, A. A. Lin, S. Arbuzova, L. E. Beckman, G. De Benedictis, P. Francalacci, A. Kouvatsi, S. Limborska, M. Marcikiae, A. Mika, B. Mika, D. Primorac, A. S. Santachiara-Benerecetti, L. L. Cavalli-Sforza, P. A. Underhill

Forensic Science Program

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651 Scopus citations

Abstract

A genetic perspective of human history in Europe was derived from 22 binary markers of the nonrecombining Y chromosome (NRY). Ten lineages account for >95% of the 1007 European Y chromosomes studied. Geographic distribution and age estimates of alleles are compatible with two Paleolithic and one Neolithic migratory episode that have contributed to the modern European gene pool. A significant correlation between the NRY haplotype data and principal components based on 95 protein markers was observed, indicating the effectiveness of NRY binary polymorphisms in the characterization of human population composition and history.

Original language	English (US)
Pages (from-to)	1155-1159
Number of pages	5
Journal	Science
Volume	290
Issue number	5494
DOIs	https://doi.org/10.1126/science.290.5494.1155
State	Published - Nov 10 2000

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Semino, O., Passarino, G., Oefner, P. J., Lin, A. A., Arbuzova, S., Beckman, L. E., De Benedictis, G., Francalacci, P., Kouvatsi, A., Limborska, S., Marcikiae, M., Mika, A., Mika, B., Primorac, D., Santachiara-Benerecetti, A. S., Cavalli-Sforza, L. L., & Underhill, P. A. (2000). The genetic legacy of paleolithic Homo sapiens sapiens in extant europeans: A Y chromosome perspective. Science, 290(5494), 1155-1159. https://doi.org/10.1126/science.290.5494.1155

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title = "The genetic legacy of paleolithic Homo sapiens sapiens in extant europeans: A Y chromosome perspective",

abstract = "A genetic perspective of human history in Europe was derived from 22 binary markers of the nonrecombining Y chromosome (NRY). Ten lineages account for >95% of the 1007 European Y chromosomes studied. Geographic distribution and age estimates of alleles are compatible with two Paleolithic and one Neolithic migratory episode that have contributed to the modern European gene pool. A significant correlation between the NRY haplotype data and principal components based on 95 protein markers was observed, indicating the effectiveness of NRY binary polymorphisms in the characterization of human population composition and history.",

author = "O. Semino and G. Passarino and Oefner, {P. J.} and Lin, {A. A.} and S. Arbuzova and Beckman, {L. E.} and {De Benedictis}, G. and P. Francalacci and A. Kouvatsi and S. Limborska and M. Marcikiae and A. Mika and B. Mika and D. Primorac and Santachiara-Benerecetti, {A. S.} and Cavalli-Sforza, {L. L.} and Underhill, {P. A.}",

year = "2000",

month = nov,

day = "10",

doi = "10.1126/science.290.5494.1155",

language = "English (US)",

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Semino, O, Passarino, G, Oefner, PJ, Lin, AA, Arbuzova, S, Beckman, LE, De Benedictis, G, Francalacci, P, Kouvatsi, A, Limborska, S, Marcikiae, M, Mika, A, Mika, B, Primorac, D, Santachiara-Benerecetti, AS, Cavalli-Sforza, LL & Underhill, PA 2000, 'The genetic legacy of paleolithic Homo sapiens sapiens in extant europeans: A Y chromosome perspective', Science, vol. 290, no. 5494, pp. 1155-1159. https://doi.org/10.1126/science.290.5494.1155

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T1 - The genetic legacy of paleolithic Homo sapiens sapiens in extant europeans

T2 - A Y chromosome perspective

AU - Semino, O.

AU - Passarino, G.

AU - Oefner, P. J.

AU - Lin, A. A.

AU - Arbuzova, S.

AU - Beckman, L. E.

AU - De Benedictis, G.

AU - Francalacci, P.

AU - Kouvatsi, A.

AU - Limborska, S.

AU - Marcikiae, M.

AU - Mika, A.

AU - Mika, B.

AU - Primorac, D.

AU - Santachiara-Benerecetti, A. S.

AU - Cavalli-Sforza, L. L.

AU - Underhill, P. A.

PY - 2000/11/10

Y1 - 2000/11/10

N2 - A genetic perspective of human history in Europe was derived from 22 binary markers of the nonrecombining Y chromosome (NRY). Ten lineages account for >95% of the 1007 European Y chromosomes studied. Geographic distribution and age estimates of alleles are compatible with two Paleolithic and one Neolithic migratory episode that have contributed to the modern European gene pool. A significant correlation between the NRY haplotype data and principal components based on 95 protein markers was observed, indicating the effectiveness of NRY binary polymorphisms in the characterization of human population composition and history.

AB - A genetic perspective of human history in Europe was derived from 22 binary markers of the nonrecombining Y chromosome (NRY). Ten lineages account for >95% of the 1007 European Y chromosomes studied. Geographic distribution and age estimates of alleles are compatible with two Paleolithic and one Neolithic migratory episode that have contributed to the modern European gene pool. A significant correlation between the NRY haplotype data and principal components based on 95 protein markers was observed, indicating the effectiveness of NRY binary polymorphisms in the characterization of human population composition and history.

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The genetic legacy of paleolithic Homo sapiens sapiens in extant europeans: A Y chromosome perspective

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