The hydroxylation of biphenyl by Aspergillus toxicarius: Conditions for a bench scale fermentation process

John H. Golbeck; John C. Cox

doi:10.1002/bit.260260506

The hydroxylation of biphenyl by Aspergillus toxicarius: Conditions for a bench scale fermentation process

John H. Golbeck, John C. Cox

Biochemistry & Molecular Biology

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11 Scopus citations

Abstract

Fungi of the Aspergillus sp. can hydroxyate biphenyl to 4,4′‐dihydroxybiphenyl, a chemical intermediate used in the plastics industry. The authors studied various batch culture conditions for the production of 4,4′‐dihydroxybiphenyl, by Aspergillus toxicarius, in 25‐mL shake flasks and 2‐L fermenter cultures. Conditions investigated included temperature, aeration, carbon and nitrogen sources, biomass content, and time of substrate addition. Under optimum conditions we observed a rate of 4,4′‐dihydroxybiphenyl production of 15–20 mg/day/g dry wt mycelia. Such a production rate is probably too low to support a commercial process and possible reasons for the low productivity are discussed.

Original language	English (US)
Pages (from-to)	434-441
Number of pages	8
Journal	Biotechnology and bioengineering
Volume	26
Issue number	5
DOIs	https://doi.org/10.1002/bit.260260506
State	Published - May 1984

All Science Journal Classification (ASJC) codes

Biotechnology
Bioengineering
Applied Microbiology and Biotechnology

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abstract = "Fungi of the Aspergillus sp. can hydroxyate biphenyl to 4,4′‐dihydroxybiphenyl, a chemical intermediate used in the plastics industry. The authors studied various batch culture conditions for the production of 4,4′‐dihydroxybiphenyl, by Aspergillus toxicarius, in 25‐mL shake flasks and 2‐L fermenter cultures. Conditions investigated included temperature, aeration, carbon and nitrogen sources, biomass content, and time of substrate addition. Under optimum conditions we observed a rate of 4,4′‐dihydroxybiphenyl production of 15–20 mg/day/g dry wt mycelia. Such a production rate is probably too low to support a commercial process and possible reasons for the low productivity are discussed.",

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AB - Fungi of the Aspergillus sp. can hydroxyate biphenyl to 4,4′‐dihydroxybiphenyl, a chemical intermediate used in the plastics industry. The authors studied various batch culture conditions for the production of 4,4′‐dihydroxybiphenyl, by Aspergillus toxicarius, in 25‐mL shake flasks and 2‐L fermenter cultures. Conditions investigated included temperature, aeration, carbon and nitrogen sources, biomass content, and time of substrate addition. Under optimum conditions we observed a rate of 4,4′‐dihydroxybiphenyl production of 15–20 mg/day/g dry wt mycelia. Such a production rate is probably too low to support a commercial process and possible reasons for the low productivity are discussed.

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The hydroxylation of biphenyl by Aspergillus toxicarius: Conditions for a bench scale fermentation process

Abstract

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