The impact of assay sensitivity in the assessment of diseases and disorders in children

Samar N. Rahhal; John S. Fuqua; Peter A. Lee

doi:10.1016/j.steroids.2008.04.014

The impact of assay sensitivity in the assessment of diseases and disorders in children

Samar N. Rahhal, John S. Fuqua, Peter A. Lee

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Accurate measurement of the low levels of testosterone (T) and estradiol (E₂) present in normal children and in children with disorders of puberty and sexual development is critical both for appropriate diagnosis and treatment and for clinical research studies. However, measurement of these levels lacks needed precision because of inadequate sensitivity of most commercially available assays and poor accuracy at the low levels found in normal childhood and most disorders. While immunoassays presently do not appear to have the potential to provide more accurate measurements, isotope dilution-gas chromatography/mass spectrometry and liquid chromatography/tandem mass spectrometry techniques offer promise to meet this need to improve clinical care and research.

Original language	English (US)
Pages (from-to)	1322-1327
Number of pages	6
Journal	Steroids
Volume	73
Issue number	13
DOIs	https://doi.org/10.1016/j.steroids.2008.04.014
State	Published - Dec 12 2008

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Biology
Endocrinology
Pharmacology
Clinical Biochemistry
Organic Chemistry

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10.1016/j.steroids.2008.04.014

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The impact of assay sensitivity in the assessment of diseases and disorders in children

Abstract

All Science Journal Classification (ASJC) codes

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