TY - JOUR
T1 - The impact of cellular senescence in cancer therapy
T2 - Is it true or not?
AU - Zhang, Yi
AU - Yang, Jin Ming
PY - 2011/10
Y1 - 2011/10
N2 - Cellular senescence is defined as the physiological program of terminal growth arrest, which can be triggered by various endogenous or exogenous stress signals. Cellular senescence can be induced in response to oncogenic activation and acts as a barrier to tumorigenesis. Moreover, tumor cells can undergo senescence when exposed to chemotherapeutic agents. In addition to suppressing tumorigenesis, senescent cells remain metabolically active and may contribute to tumor formation and to therapy resistance. In the current review, we discuss the molecular regulation of cellular senescence, the potential implications of senescence in human cancers, and the possibility of exploiting cellular senescence for the treatment of cancers.
AB - Cellular senescence is defined as the physiological program of terminal growth arrest, which can be triggered by various endogenous or exogenous stress signals. Cellular senescence can be induced in response to oncogenic activation and acts as a barrier to tumorigenesis. Moreover, tumor cells can undergo senescence when exposed to chemotherapeutic agents. In addition to suppressing tumorigenesis, senescent cells remain metabolically active and may contribute to tumor formation and to therapy resistance. In the current review, we discuss the molecular regulation of cellular senescence, the potential implications of senescence in human cancers, and the possibility of exploiting cellular senescence for the treatment of cancers.
UR - http://www.scopus.com/inward/record.url?scp=80053924285&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80053924285&partnerID=8YFLogxK
U2 - 10.1038/aps.2011.108
DO - 10.1038/aps.2011.108
M3 - Review article
C2 - 21909124
AN - SCOPUS:80053924285
SN - 1671-4083
VL - 32
SP - 1199
EP - 1207
JO - Acta Pharmacologica Sinica
JF - Acta Pharmacologica Sinica
IS - 10
ER -