The Implication of Cardiac Injury Score on In-hospital Mortality of Coronavirus Disease 2019

In Cheol Kim, Jin Eun Song, Hee Jung Lee, Jeong Ho Park, Miri Hyun, Ji Yeon Lee, Hyun Ah Kim, Yong Shik Kwon, Jae Seok Park, Jong Chan Youn, Jongmin Hwang, Cheol Hyun Lee, Yun Kyeong Cho, Hyoung Seob Park, Hyuck Jun Yoon, Chang Wook Nam, Seongwook Han, Seung Ho Hur, Howard J. Eisen, Hyungseop Kim

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Backgrounds: The severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) has spread worldwide. Cardiac injury after SARS-CoV-2 infection is a major concern. The present study investigated impact of the biomarkers indicating cardiac injury in coronavirus disease 2019 (COVID-19) on patients’ outcomes. Methods: This study enrolled patients who were confirmed to have COVID-19 and admitted at a tertiary university referral hospital between February 19, 2020 and March 15, 2020. Cardiac injury was defined as an abnormality in one of the following result markers: 1) myocardial damage marker (creatine kinase-MB or troponin-I), 2) heart failure marker (N-terminal-pro B-type natriuretic peptide), and 3) electrical abnormality marker (electrocardiography). The relationship between each cardiac injury marker and mortality was evaluated. Survival analysis of mortality according to the scoring by numbers of cardiac injury markers was also performed. Results: A total of 38 patients with COVID-19 were enrolled. Twenty-two patients (57.9%) had at least one of cardiac injury markers. The patients with cardiac injuries were older (69.6 ± 14.9 vs. 58.6 ± 13.9 years old, P = 0.026), and were more male (59.1% vs. 18.8%, P= 0.013). They showed lower initial oxygen saturation (92.8 vs. 97.1%, P = 0.002) and a trend toward higher mortality (27.3 vs. 6.3%, P = 0.099). The increased number of cardiac injury markers was significantly related to a higher incidence of in-hospital mortality which was also evidenced by Kaplan-Meier survival analysis (P= 0.008). Conclusion: The increased number of cardiac injury markers is related to in-hospital mortality in patients with COVID-19.

Original languageEnglish (US)
Article numbere349
JournalJournal of Korean Medical Science
Issue number39
StatePublished - Oct 2020

All Science Journal Classification (ASJC) codes

  • General Medicine


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