The importance of type IV hyperlipoproteinemia as a predisposing factor in coronary artery disease

Antone F. Salel, Kay Riggs, Dean T. Mason, Ezra A. Amsterdam, Robert Zelis

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One hundred seventy-six consecutive patients were evaluated for the frequency of potentially reversible risk factors associated with coronary artery disease. The results In a group of 105 patients with objective coronary artery disease was compared with a control group of 71 patients without coronary disease. The prevalence of risk factors was examined in the entire group of 176 patients and in a young subgroup of 55 patients with coronary disease who were under 50 years of age. Obesity was the most prevalent risk factor for the whole group but was especially significant for the young patient with coronary disease. Type IV hyperlipoproteinemia, the most prevalent lipoprotein disorder in the study, was significantly elevated in the entire group as well as in the young patients with coronary disease. An abnormal glucose tolerance test was another feature of the young patients with coronary disease. Although some men with coronary disease did not have a predisposing metabolic abnormality, no woman in the study had coronary disease if a metabolic abnormality was not present. These findings emphasize the metabolic nature of coronary artery disease as well as the atherogenic potential of type IV hyperlipoproteinemia.

Original languageEnglish (US)
Pages (from-to)897-903
Number of pages7
JournalThe American journal of medicine
Issue number6
StatePublished - Jan 1 1974

All Science Journal Classification (ASJC) codes

  • General Medicine


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