The induction of spermidine/spermine N1-acetyltransferase (SSAT) is a common event in the response of human primary non-small cell lung carcinomas to exposure to the new antitumor polyamine analogue N1,N11- bis(ethyl)norspermine

Edward W. Gabrielson, Anthony E. Pegg, Robert A. Casero

    Research output: Contribution to journalArticlepeer-review

    39 Scopus citations

    Abstract

    Several new polyamine analogues have been developed for the treatment of human solid tumors. The phenotype-specific activity of some of these analogues has been associated with the superinduction of the rate-limiting enzyme in polyamine catabolism spermidine/spermine N1-acetyltransferase (SSAT). Using immunohistochemistry, we found a majority (64%) of human primary lung cancer explants to exhibit high expression of SSAT after treatment with 10 μM N1,N11-bis(ethyl)norspermine, an agent currently undergoing Phase II clinical trials against several important human solid tumors. The staining of SSAT was found specifically in the tumor tissue and not in the neighboring normal lung tissue. These results demonstrate the ability to detect induction of SSAT in clinical specimens and suggest the potential of this test as a prognostic indicator of drug response.

    Original languageEnglish (US)
    Pages (from-to)1638-1641
    Number of pages4
    JournalClinical Cancer Research
    Volume5
    Issue number7
    StatePublished - Jul 1999

    All Science Journal Classification (ASJC) codes

    • Oncology
    • Cancer Research

    Fingerprint

    Dive into the research topics of 'The induction of spermidine/spermine N1-acetyltransferase (SSAT) is a common event in the response of human primary non-small cell lung carcinomas to exposure to the new antitumor polyamine analogue N1,N11- bis(ethyl)norspermine'. Together they form a unique fingerprint.

    Cite this