The influence of neuropathology on the fMRI Signal: A measurement of brain or vein?

F. G. Hillary; B. Biswal

doi:10.1080/13854040601064542

The influence of neuropathology on the fMRI Signal: A measurement of brain or vein?

F. G. Hillary, B. Biswal

Research output: Contribution to journal › Review article › peer-review

30 Scopus citations

Abstract

There is a rapidly growing literature using fMRI technology to investigate the various forms of behavioral impairment associated with brain injury and disease. Given this, surprisingly little work has been conducted to examine the influence of neuropathophysiological processes on the fMRI signal. This paper reviews the literature examining baseline alteration in cerebrovascular parameters associated with normal aging, brain injury, and brain disease. In addition, findings from three cases of individuals with severe brain trauma will be presented to show the influence of brain trauma on baseline cerebrovascular parameters measured by fMRI. The methods used here can be implemented by other investigators to accurately isolate specific hemodynamic changes that can influence the BOLD fMRI signal.

Original language	English (US)
Pages (from-to)	58-72
Number of pages	15
Journal	Clinical Neuropsychologist
Volume	21
Issue number	1
DOIs	https://doi.org/10.1080/13854040601064542
State	Published - Jan 2007

All Science Journal Classification (ASJC) codes

Neuropsychology and Physiological Psychology
Developmental and Educational Psychology
Clinical Psychology
Arts and Humanities (miscellaneous)
Psychiatry and Mental health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/13854040601064542

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title = "The influence of neuropathology on the fMRI Signal: A measurement of brain or vein?",

abstract = "There is a rapidly growing literature using fMRI technology to investigate the various forms of behavioral impairment associated with brain injury and disease. Given this, surprisingly little work has been conducted to examine the influence of neuropathophysiological processes on the fMRI signal. This paper reviews the literature examining baseline alteration in cerebrovascular parameters associated with normal aging, brain injury, and brain disease. In addition, findings from three cases of individuals with severe brain trauma will be presented to show the influence of brain trauma on baseline cerebrovascular parameters measured by fMRI. The methods used here can be implemented by other investigators to accurately isolate specific hemodynamic changes that can influence the BOLD fMRI signal.",

author = "Hillary, {F. G.} and B. Biswal",

note = "Funding Information: This research was supported in part by NIH grant HD07522, NIDRR grant H133P970011, and a grant from the Henry H. Kessler Foundation and the Hyde & Watson Foundation, West Orange, Jersey.",

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The influence of neuropathology on the fMRI Signal: A measurement of brain or vein?

Abstract

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