TY - JOUR
T1 - The influence of retinal innervation on neurogenesis in the first optic ganglion of drosophila
AU - Selleck, Scott B.
AU - Steller, Hermann
N1 - Funding Information:
We would like to thank Drs. E. Bier, Y. N. Jan, L. Jan, S. Robinow, K. White, and S. Benzer for kindly providing neuron-specific antibodies used in this study. We are grateful to Don Doering for introducing us to the use of the confocal microscope. We thank Drs. C. Bargmann, R. Hynes, R. MacKay, S. Robinow, D. Vollrath, T. Orr-Weaver, K. White, and our colleagues in the Steller lab for their comments on a draft of this manuscript. We also thank Drs. A. Hofbauer and J. Campos-Ortega for sharing results prior to publication. Some of the BUdR pulse-chase analyses were conducted in the laboratory of Dr. K. White, Brandeis University. This research was supported by National Institutes of Health grant ROl-NS26451 and a Pew Scholars Award to H. S. S. 8. S. is a Burroughs Wellcome Fund Fellow of the Life Sciences Research Foundation. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement”in accordance with 18 USC Section 1734 solely to indicate this fact.
PY - 1991/1
Y1 - 1991/1
N2 - We have examined the influence of retinal innervation on the development of target neurons in the first optic ganglion, the lamina, of D. melanogaster. Mitotically active lamina precursor cells (LPCs), which normally produce lamina neurons, are absent in mutants that lack retinal innervation, while other proliferative centers appear unaffected. Reducing the number of innervating photoreceptor axons results in fewer mitotic LPCs. In glass mutants photoreceptors project to abnormal locations and LPCs are found adjacent to these aberrant projections. We conclude that the arrival of photoreceptor axons in the larval brain initiates, directly or indirectly, cell division to produce lamina neurons. Our results provide an explanation for how the synchronous development of these two interacting systems is coordinated.
AB - We have examined the influence of retinal innervation on the development of target neurons in the first optic ganglion, the lamina, of D. melanogaster. Mitotically active lamina precursor cells (LPCs), which normally produce lamina neurons, are absent in mutants that lack retinal innervation, while other proliferative centers appear unaffected. Reducing the number of innervating photoreceptor axons results in fewer mitotic LPCs. In glass mutants photoreceptors project to abnormal locations and LPCs are found adjacent to these aberrant projections. We conclude that the arrival of photoreceptor axons in the larval brain initiates, directly or indirectly, cell division to produce lamina neurons. Our results provide an explanation for how the synchronous development of these two interacting systems is coordinated.
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U2 - 10.1016/0896-6273(91)90124-I
DO - 10.1016/0896-6273(91)90124-I
M3 - Article
C2 - 1898850
AN - SCOPUS:0026085328
SN - 0896-6273
VL - 6
SP - 83
EP - 99
JO - Neuron
JF - Neuron
IS - 1
ER -