The integrity of liver protein synthesis in male rats treated with 1,2-dibromo-3-chloropropane

D. E. Moody; O. A. Clawson; E. A. Smuckler

doi:10.1016/0378-4274(82)90171-0

The integrity of liver protein synthesis in male rats treated with 1,2-dibromo-3-chloropropane

D. E. Moody, O. A. Clawson, E. A. Smuckler

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Abstract

Male rats treated with a single dose of 1,2-dibromo-3-chloropropane (DBCP) were tested for their ability to carry out the synthesis of liver proteins. In animals treated for 12 h, we found no changes in the uptake of [¹⁴C]orotic acid into liver RNA or the uptake of [³H]leucine into liver or serum protein. Uptake of [³H]leucine into the soluble fraction of the enlarged liver increased in proportion to liver size, while the uptake of [¹⁴C]orotic acid was unchanged. Examination of the ultrastructure of liver cells from rats treated for 12, 24, or 48 h revealed that the structure of the rough and smooth endoplasmic reticulum (RER; SER) were modified. An absence of ordered stacks of the RER and the presence of tangled nets of SER were noted.

Original language	English (US)
Pages (from-to)	101-108
Number of pages	8
Journal	Toxicology Letters
Volume	12
Issue number	2-3
DOIs	https://doi.org/10.1016/0378-4274(82)90171-0
State	Published - Jul 1982

All Science Journal Classification (ASJC) codes

Toxicology

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title = "The integrity of liver protein synthesis in male rats treated with 1,2-dibromo-3-chloropropane",

abstract = "Male rats treated with a single dose of 1,2-dibromo-3-chloropropane (DBCP) were tested for their ability to carry out the synthesis of liver proteins. In animals treated for 12 h, we found no changes in the uptake of [14C]orotic acid into liver RNA or the uptake of [3H]leucine into liver or serum protein. Uptake of [3H]leucine into the soluble fraction of the enlarged liver increased in proportion to liver size, while the uptake of [14C]orotic acid was unchanged. Examination of the ultrastructure of liver cells from rats treated for 12, 24, or 48 h revealed that the structure of the rough and smooth endoplasmic reticulum (RER; SER) were modified. An absence of ordered stacks of the RER and the presence of tangled nets of SER were noted.",

author = "Moody, {D. E.} and Clawson, {O. A.} and Smuckler, {E. A.}",

note = "Funding Information: This work was supportedb y USPHS Grant AM-19843a nd CA-21141,a nd by a Monsanto Fund Fellowshipi n Toxicology.",

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AU - Moody, D. E.

AU - Clawson, O. A.

AU - Smuckler, E. A.

N1 - Funding Information: This work was supportedb y USPHS Grant AM-19843a nd CA-21141,a nd by a Monsanto Fund Fellowshipi n Toxicology.

PY - 1982/7

Y1 - 1982/7

N2 - Male rats treated with a single dose of 1,2-dibromo-3-chloropropane (DBCP) were tested for their ability to carry out the synthesis of liver proteins. In animals treated for 12 h, we found no changes in the uptake of [14C]orotic acid into liver RNA or the uptake of [3H]leucine into liver or serum protein. Uptake of [3H]leucine into the soluble fraction of the enlarged liver increased in proportion to liver size, while the uptake of [14C]orotic acid was unchanged. Examination of the ultrastructure of liver cells from rats treated for 12, 24, or 48 h revealed that the structure of the rough and smooth endoplasmic reticulum (RER; SER) were modified. An absence of ordered stacks of the RER and the presence of tangled nets of SER were noted.

AB - Male rats treated with a single dose of 1,2-dibromo-3-chloropropane (DBCP) were tested for their ability to carry out the synthesis of liver proteins. In animals treated for 12 h, we found no changes in the uptake of [14C]orotic acid into liver RNA or the uptake of [3H]leucine into liver or serum protein. Uptake of [3H]leucine into the soluble fraction of the enlarged liver increased in proportion to liver size, while the uptake of [14C]orotic acid was unchanged. Examination of the ultrastructure of liver cells from rats treated for 12, 24, or 48 h revealed that the structure of the rough and smooth endoplasmic reticulum (RER; SER) were modified. An absence of ordered stacks of the RER and the presence of tangled nets of SER were noted.

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ER -

The integrity of liver protein synthesis in male rats treated with 1,2-dibromo-3-chloropropane

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