The integrity of liver protein synthesis in male rats treated with 1,2-dibromo-3-chloropropane

D. E. Moody; O. A. Clawson; E. A. Smuckler

doi:10.1016/0378-4274(82)90171-0

The integrity of liver protein synthesis in male rats treated with 1,2-dibromo-3-chloropropane

D. E. Moody
, O. A. Clawson
, E. A. Smuckler

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Male rats treated with a single dose of 1,2-dibromo-3-chloropropane (DBCP) were tested for their ability to carry out the synthesis of liver proteins. In animals treated for 12 h, we found no changes in the uptake of [¹⁴C]orotic acid into liver RNA or the uptake of [³H]leucine into liver or serum protein. Uptake of [³H]leucine into the soluble fraction of the enlarged liver increased in proportion to liver size, while the uptake of [¹⁴C]orotic acid was unchanged. Examination of the ultrastructure of liver cells from rats treated for 12, 24, or 48 h revealed that the structure of the rough and smooth endoplasmic reticulum (RER; SER) were modified. An absence of ordered stacks of the RER and the presence of tangled nets of SER were noted.

Original language	English (US)
Pages (from-to)	101-108
Number of pages	8
Journal	Toxicology Letters
Volume	12
Issue number	2-3
DOIs	https://doi.org/10.1016/0378-4274(82)90171-0
State	Published - Jul 1982

All Science Journal Classification (ASJC) codes

Toxicology

Access to Document

10.1016/0378-4274(82)90171-0

Cite this

@article{90c3a04b18d0483caa0995c94e50a735,

title = "The integrity of liver protein synthesis in male rats treated with 1,2-dibromo-3-chloropropane",

abstract = "Male rats treated with a single dose of 1,2-dibromo-3-chloropropane (DBCP) were tested for their ability to carry out the synthesis of liver proteins. In animals treated for 12 h, we found no changes in the uptake of [14C]orotic acid into liver RNA or the uptake of [3H]leucine into liver or serum protein. Uptake of [3H]leucine into the soluble fraction of the enlarged liver increased in proportion to liver size, while the uptake of [14C]orotic acid was unchanged. Examination of the ultrastructure of liver cells from rats treated for 12, 24, or 48 h revealed that the structure of the rough and smooth endoplasmic reticulum (RER; SER) were modified. An absence of ordered stacks of the RER and the presence of tangled nets of SER were noted.",

author = "Moody, \{D. E.\} and Clawson, \{O. A.\} and Smuckler, \{E. A.\}",

note = "Funding Information: This work was supportedb y USPHS Grant AM-19843a nd CA-21141,a nd by a Monsanto Fund Fellowshipi n Toxicology.",

year = "1982",

month = jul,

doi = "10.1016/0378-4274(82)90171-0",

language = "English (US)",

volume = "12",

pages = "101--108",

journal = "Toxicology Letters",

issn = "0378-4274",

publisher = "Elsevier Ireland Ltd",

number = "2-3",

}

TY - JOUR

T1 - The integrity of liver protein synthesis in male rats treated with 1,2-dibromo-3-chloropropane

AU - Moody, D. E.

AU - Clawson, O. A.

AU - Smuckler, E. A.

N1 - Funding Information: This work was supportedb y USPHS Grant AM-19843a nd CA-21141,a nd by a Monsanto Fund Fellowshipi n Toxicology.

PY - 1982/7

Y1 - 1982/7

N2 - Male rats treated with a single dose of 1,2-dibromo-3-chloropropane (DBCP) were tested for their ability to carry out the synthesis of liver proteins. In animals treated for 12 h, we found no changes in the uptake of [14C]orotic acid into liver RNA or the uptake of [3H]leucine into liver or serum protein. Uptake of [3H]leucine into the soluble fraction of the enlarged liver increased in proportion to liver size, while the uptake of [14C]orotic acid was unchanged. Examination of the ultrastructure of liver cells from rats treated for 12, 24, or 48 h revealed that the structure of the rough and smooth endoplasmic reticulum (RER; SER) were modified. An absence of ordered stacks of the RER and the presence of tangled nets of SER were noted.

AB - Male rats treated with a single dose of 1,2-dibromo-3-chloropropane (DBCP) were tested for their ability to carry out the synthesis of liver proteins. In animals treated for 12 h, we found no changes in the uptake of [14C]orotic acid into liver RNA or the uptake of [3H]leucine into liver or serum protein. Uptake of [3H]leucine into the soluble fraction of the enlarged liver increased in proportion to liver size, while the uptake of [14C]orotic acid was unchanged. Examination of the ultrastructure of liver cells from rats treated for 12, 24, or 48 h revealed that the structure of the rough and smooth endoplasmic reticulum (RER; SER) were modified. An absence of ordered stacks of the RER and the presence of tangled nets of SER were noted.

UR - https://www.scopus.com/pages/publications/0020291757

UR - https://www.scopus.com/pages/publications/0020291757#tab=citedBy

U2 - 10.1016/0378-4274(82)90171-0

DO - 10.1016/0378-4274(82)90171-0

M3 - Article

C2 - 6180525

AN - SCOPUS:0020291757

SN - 0378-4274

VL - 12

SP - 101

EP - 108

JO - Toxicology Letters

JF - Toxicology Letters

IS - 2-3

ER -

The integrity of liver protein synthesis in male rats treated with 1,2-dibromo-3-chloropropane

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this