The interaction of Cl- with a gramicidin-like channel

Shen Shu Sung; Peter C. Jordan

doi:10.1016/0301-4622(87)80041-8

The interaction of Cl^- with a gramicidin-like channel

Shen Shu Sung
, Peter C. Jordan

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Molecular dynamics simulations have been used to study the interaction of Cl^- with a gramicidin-like channel. The results suggest that there is a high-energy barrier at the entrance of the channel, which would correspond to a permeability 10^-9-times that of a cation of the same size. This could account for the cationic selectivity of the gramicidin channel and indicates that valence selectivity is kinetically controlled.

Original language	English (US)
Pages (from-to)	1-6
Number of pages	6
Journal	Biophysical Chemistry
Volume	27
Issue number	1
DOIs	https://doi.org/10.1016/0301-4622(87)80041-8
State	Published - Jul 1987

All Science Journal Classification (ASJC) codes

Biophysics
Biochemistry
Organic Chemistry

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10.1016/0301-4622(87)80041-8

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title = "The interaction of Cl- with a gramicidin-like channel",

abstract = "Molecular dynamics simulations have been used to study the interaction of Cl- with a gramicidin-like channel. The results suggest that there is a high-energy barrier at the entrance of the channel, which would correspond to a permeability 10-9-times that of a cation of the same size. This could account for the cationic selectivity of the gramicidin channel and indicates that valence selectivity is kinetically controlled.",

author = "Sung, \{Shen Shu\} and Jordan, \{Peter C.\}",

note = "Funding Information: This work has been supported by NIH grant GM-28643.",

year = "1987",

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AU - Jordan, Peter C.

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Y1 - 1987/7

N2 - Molecular dynamics simulations have been used to study the interaction of Cl- with a gramicidin-like channel. The results suggest that there is a high-energy barrier at the entrance of the channel, which would correspond to a permeability 10-9-times that of a cation of the same size. This could account for the cationic selectivity of the gramicidin channel and indicates that valence selectivity is kinetically controlled.

AB - Molecular dynamics simulations have been used to study the interaction of Cl- with a gramicidin-like channel. The results suggest that there is a high-energy barrier at the entrance of the channel, which would correspond to a permeability 10-9-times that of a cation of the same size. This could account for the cationic selectivity of the gramicidin channel and indicates that valence selectivity is kinetically controlled.

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U2 - 10.1016/0301-4622(87)80041-8

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The interaction of Cl^- with a gramicidin-like channel

Abstract

All Science Journal Classification (ASJC) codes

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