The major histocompatibility complex and human evolution

Jan Klein, Jutta Gutknecht, Norbert Fischer

Research output: Contribution to journalArticlepeer-review

54 Scopus citations


Many alleles at the human major histocompatibility complex (HLA) loci diverged before the divergence of humans and great apes from a common ancestor. This fact puts a lower limit on the size of the bottleneck in human evolution: the genus Homo must have been founded by no less than ten and probably by more than 10 000 individuals.

Original languageEnglish (US)
Pages (from-to)7-11
Number of pages5
JournalTrends in Genetics
Issue numberC
StatePublished - 1990

All Science Journal Classification (ASJC) codes

  • Genetics


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