The major histocompatibility complex and human evolution

Jan Klein; Jutta Gutknecht; Norbert Fischer

doi:10.1016/0168-9525(90)90042-5

The major histocompatibility complex and human evolution

Jan Klein
, Jutta Gutknecht
, Norbert Fischer

Biology

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

Many alleles at the human major histocompatibility complex (HLA) loci diverged before the divergence of humans and great apes from a common ancestor. This fact puts a lower limit on the size of the bottleneck in human evolution: the genus Homo must have been founded by no less than ten and probably by more than 10 000 individuals.

Original language	English (US)
Pages (from-to)	7-11
Number of pages	5
Journal	Trends in Genetics
Volume	6
Issue number	C
DOIs	https://doi.org/10.1016/0168-9525(90)90042-5
State	Published - 1990

All Science Journal Classification (ASJC) codes

Genetics

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10.1016/0168-9525(90)90042-5

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title = "The major histocompatibility complex and human evolution",

abstract = "Many alleles at the human major histocompatibility complex (HLA) loci diverged before the divergence of humans and great apes from a common ancestor. This fact puts a lower limit on the size of the bottleneck in human evolution: the genus Homo must have been founded by no less than ten and probably by more than 10 000 individuals.",

author = "Jan Klein and Jutta Gutknecht and Norbert Fischer",

note = "Funding Information: We thank Ms Lynne Yakes for editorial assistance. Our experimental work cited in this communication was supported in part by grant No. RO1 A123667 from the National Institutes of Health.",

year = "1990",

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AU - Klein, Jan

AU - Gutknecht, Jutta

AU - Fischer, Norbert

N1 - Funding Information: We thank Ms Lynne Yakes for editorial assistance. Our experimental work cited in this communication was supported in part by grant No. RO1 A123667 from the National Institutes of Health.

PY - 1990

Y1 - 1990

N2 - Many alleles at the human major histocompatibility complex (HLA) loci diverged before the divergence of humans and great apes from a common ancestor. This fact puts a lower limit on the size of the bottleneck in human evolution: the genus Homo must have been founded by no less than ten and probably by more than 10 000 individuals.

AB - Many alleles at the human major histocompatibility complex (HLA) loci diverged before the divergence of humans and great apes from a common ancestor. This fact puts a lower limit on the size of the bottleneck in human evolution: the genus Homo must have been founded by no less than ten and probably by more than 10 000 individuals.

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U2 - 10.1016/0168-9525(90)90042-5

DO - 10.1016/0168-9525(90)90042-5

M3 - Article

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AN - SCOPUS:0025056803

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EP - 11

JO - Trends in Genetics

JF - Trends in Genetics

IS - C

ER -

The major histocompatibility complex and human evolution

Abstract

All Science Journal Classification (ASJC) codes

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