The mammalian TRPC cation channels

Guillermo Vazquez, Barbara J. Wedel, Omar Aziz, Mohamed Trebak, James W. Putney

Research output: Contribution to journalArticlepeer-review

283 Scopus citations


Transient Receptor Potential-Canonical (TRPC) channels are mammalian homologs of Transient Receptor Potential (TRP), a Ca 2+-permeable channel involved in the phospholipase C-regulated photoreceptor activation mechanism in Drosophila. The seven mammalian TRPCs constitute a family of channels which have been proposed to function as store-operated as well as second messenger-operated channels in a variety of cell types. TRPC channels, together with other more distantly related channel families, make up the larger TRP channel superfamily. This review summarizes recent findings on the structure, regulation and function of the apparently ubiquitous TRPC cation channels.

Original languageEnglish (US)
Pages (from-to)21-36
Number of pages16
JournalBiochimica et Biophysica Acta - Molecular Cell Research
Issue number1-3
StatePublished - Dec 6 2004

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology


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