The many faces of β-TrCP E3 ubiquitin ligases: Reflections in the magic mirror of cancer

Serge Y. Fuchs; Vladimir S. Spiegelman; K. G.Suresh Kumar

doi:10.1038/sj.onc.1207389

The many faces of β-TrCP E3 ubiquitin ligases: Reflections in the magic mirror of cancer

Serge Y. Fuchs, Vladimir S. Spiegelman, K. G.Suresh Kumar

Research output: Contribution to journal › Review article › peer-review

280 Scopus citations

Abstract

Beta-transducin repeats-containing proteins (β-TrCP) serve as the substrate recognition subunits for the SCF^β-TrCP E3 ubiquitin ligases. These ligases ubiquitinate specifically phosphorylated substrates and play a pivotal role in the regulation of cell division and various signal transduction pathways, which, in turn, are essential for many aspects of tumorigenesis. We review the functions of the SCF^β-TrCP ligases in the light of their relevance to cell growth, survival and transformation. Mechanisms underlying β-TrCP regulation and their aberration in human and animal cancer as well as prospective of targeting β-TrCP as a means of anticancer therapy are also discussed.

Original language	English (US)
Pages (from-to)	2028-2036
Number of pages	9
Journal	Oncogene
Volume	23
Issue number	11 REV. ISS. 1
DOIs	https://doi.org/10.1038/sj.onc.1207389
State	Published - Mar 15 2004

All Science Journal Classification (ASJC) codes

Molecular Biology
Genetics
Cancer Research

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/sj.onc.1207389

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title = "The many faces of β-TrCP E3 ubiquitin ligases: Reflections in the magic mirror of cancer",

abstract = "Beta-transducin repeats-containing proteins (β-TrCP) serve as the substrate recognition subunits for the SCFβ-TrCP E3 ubiquitin ligases. These ligases ubiquitinate specifically phosphorylated substrates and play a pivotal role in the regulation of cell division and various signal transduction pathways, which, in turn, are essential for many aspects of tumorigenesis. We review the functions of the SCFβ-TrCP ligases in the light of their relevance to cell growth, survival and transformation. Mechanisms underlying β-TrCP regulation and their aberration in human and animal cancer as well as prospective of targeting β-TrCP as a means of anticancer therapy are also discussed.",

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note = "Funding Information: Support from the NCI Grant CA 92900 (to SYF) and American Cancer Society award RSG-02-140-01-CNE (to VSS) is gratefully acknowledged.",

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N1 - Funding Information: Support from the NCI Grant CA 92900 (to SYF) and American Cancer Society award RSG-02-140-01-CNE (to VSS) is gratefully acknowledged.

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AB - Beta-transducin repeats-containing proteins (β-TrCP) serve as the substrate recognition subunits for the SCFβ-TrCP E3 ubiquitin ligases. These ligases ubiquitinate specifically phosphorylated substrates and play a pivotal role in the regulation of cell division and various signal transduction pathways, which, in turn, are essential for many aspects of tumorigenesis. We review the functions of the SCFβ-TrCP ligases in the light of their relevance to cell growth, survival and transformation. Mechanisms underlying β-TrCP regulation and their aberration in human and animal cancer as well as prospective of targeting β-TrCP as a means of anticancer therapy are also discussed.

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The many faces of β-TrCP E3 ubiquitin ligases: Reflections in the magic mirror of cancer

Abstract

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