The Mohawk homeobox gene is a critical regulator of tendon differentiation

Yoshiaki Ito; Naoya Toriuchi; Teruhito Yoshitaka; Hiroe Ueno-Kudoh; Tempei Sato; Shigetoshi Yokoyama; Keiichiro Nishida; Takayuki Akimoto; Michiko Takahashi; Shigeru Miyaki; Hiroshi Asahara

doi:10.1073/pnas.1000525107

The Mohawk homeobox gene is a critical regulator of tendon differentiation

Yoshiaki Ito
, Naoya Toriuchi
, Teruhito Yoshitaka
, Hiroe Ueno-Kudoh
, Tempei Sato
, Shigetoshi Yokoyama
, Keiichiro Nishida
, Takayuki Akimoto
, Michiko Takahashi
, Shigeru Miyaki
, Hiroshi Asahara

Huck Institutes of the Life Sciences

Research output: Contribution to journal › Article › peer-review

272 Scopus citations

Abstract

Mohawk(Mkx) is a member of the Three Amino acid Loop Extension superclass of atypical homeobox genes that is expressed in developing tendons. To investigate the in vivo functions of Mkx, we generated Mkx^-/- mice. These mice had hypoplastic tendons throughout the body. Despite the reduction in tendon mass, the cell number in tail tendon fiber bundles was similar between wild-type and Mkx^-/- mice. We also observed small collagen fibril diameters and a down-regulation of type I collagen in Mkx^-/- tendons. These data indicate that Mkx plays a critical role in tendon differentiation by regulating type I collagen production in tendon cells.

Original language	English (US)
Pages (from-to)	10538-10542
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	107
Issue number	23
DOIs	https://doi.org/10.1073/pnas.1000525107
State	Published - Jun 8 2010

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10.1073/pnas.1000525107

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Ito, Y., Toriuchi, N., Yoshitaka, T., Ueno-Kudoh, H., Sato, T., Yokoyama, S., Nishida, K., Akimoto, T., Takahashi, M., Miyaki, S., & Asahara, H. (2010). The Mohawk homeobox gene is a critical regulator of tendon differentiation. Proceedings of the National Academy of Sciences of the United States of America, 107(23), 10538-10542. https://doi.org/10.1073/pnas.1000525107

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title = "The Mohawk homeobox gene is a critical regulator of tendon differentiation",

abstract = "Mohawk(Mkx) is a member of the Three Amino acid Loop Extension superclass of atypical homeobox genes that is expressed in developing tendons. To investigate the in vivo functions of Mkx, we generated Mkx-/- mice. These mice had hypoplastic tendons throughout the body. Despite the reduction in tendon mass, the cell number in tail tendon fiber bundles was similar between wild-type and Mkx-/- mice. We also observed small collagen fibril diameters and a down-regulation of type I collagen in Mkx-/- tendons. These data indicate that Mkx plays a critical role in tendon differentiation by regulating type I collagen production in tendon cells.",

author = "Yoshiaki Ito and Naoya Toriuchi and Teruhito Yoshitaka and Hiroe Ueno-Kudoh and Tempei Sato and Shigetoshi Yokoyama and Keiichiro Nishida and Takayuki Akimoto and Michiko Takahashi and Shigeru Miyaki and Hiroshi Asahara",

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doi = "10.1073/pnas.1000525107",

language = "English (US)",

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Ito, Y, Toriuchi, N, Yoshitaka, T, Ueno-Kudoh, H, Sato, T, Yokoyama, S, Nishida, K, Akimoto, T, Takahashi, M, Miyaki, S & Asahara, H 2010, 'The Mohawk homeobox gene is a critical regulator of tendon differentiation', Proceedings of the National Academy of Sciences of the United States of America, vol. 107, no. 23, pp. 10538-10542. https://doi.org/10.1073/pnas.1000525107

TY - JOUR

T1 - The Mohawk homeobox gene is a critical regulator of tendon differentiation

AU - Ito, Yoshiaki

AU - Toriuchi, Naoya

AU - Yoshitaka, Teruhito

AU - Ueno-Kudoh, Hiroe

AU - Sato, Tempei

AU - Yokoyama, Shigetoshi

AU - Nishida, Keiichiro

AU - Akimoto, Takayuki

AU - Takahashi, Michiko

AU - Miyaki, Shigeru

AU - Asahara, Hiroshi

PY - 2010/6/8

Y1 - 2010/6/8

N2 - Mohawk(Mkx) is a member of the Three Amino acid Loop Extension superclass of atypical homeobox genes that is expressed in developing tendons. To investigate the in vivo functions of Mkx, we generated Mkx-/- mice. These mice had hypoplastic tendons throughout the body. Despite the reduction in tendon mass, the cell number in tail tendon fiber bundles was similar between wild-type and Mkx-/- mice. We also observed small collagen fibril diameters and a down-regulation of type I collagen in Mkx-/- tendons. These data indicate that Mkx plays a critical role in tendon differentiation by regulating type I collagen production in tendon cells.

AB - Mohawk(Mkx) is a member of the Three Amino acid Loop Extension superclass of atypical homeobox genes that is expressed in developing tendons. To investigate the in vivo functions of Mkx, we generated Mkx-/- mice. These mice had hypoplastic tendons throughout the body. Despite the reduction in tendon mass, the cell number in tail tendon fiber bundles was similar between wild-type and Mkx-/- mice. We also observed small collagen fibril diameters and a down-regulation of type I collagen in Mkx-/- tendons. These data indicate that Mkx plays a critical role in tendon differentiation by regulating type I collagen production in tendon cells.

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U2 - 10.1073/pnas.1000525107

DO - 10.1073/pnas.1000525107

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C2 - 20498044

AN - SCOPUS:77953776267

SN - 0027-8424

VL - 107

SP - 10538

EP - 10542

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 23

ER -

The Mohawk homeobox gene is a critical regulator of tendon differentiation

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