The Myofibroblastic Component of Rubeosis Iridis

Thomas John; Joseph W. Sassani; Ralph C. Eagle

doi:10.1016/S0161-6420(83)34520-6

The Myofibroblastic Component of Rubeosis Iridis

Thomas John, Joseph W. Sassani, Ralph C. Eagle

Research output: Contribution to journal › Article › peer-review

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Abstract

Nineteen blind eyes enucleated for painful angle closure-glaucoma secondary to iris neovascularization (rubeosis iridis) were examined by scanning electron microscopy and correlative light and transmission electron microscopy. Fresh and deparaffinized tissue from patients with diabetes mellitus, central retinal vein occlusion, and retinoblastoma were studied. Scanning electron microscopy revealed extensive peripheral anterior synechia formation and flattening and effacement of the anterior iridic surface by a confluent fibrovascular membrane. New vessels on the anterior iris uniformly were hidden beneath a clinically inapparent, superficial layer of myofibroblasts, ie, fibroblastic cells with smooth muscle differentiation. Myofibroblasts may provide the motive force for synechial closure and ectropion iridis in neovascular glaucoma.

Original language	English (US)
Pages (from-to)	721-728
Number of pages	8
Journal	Ophthalmology
Volume	90
Issue number	6
DOIs	https://doi.org/10.1016/S0161-6420(83)34520-6
State	Published - 1983

All Science Journal Classification (ASJC) codes

Ophthalmology

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0161-6420(83)34520-6

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title = "The Myofibroblastic Component of Rubeosis Iridis",

abstract = "Nineteen blind eyes enucleated for painful angle closure-glaucoma secondary to iris neovascularization (rubeosis iridis) were examined by scanning electron microscopy and correlative light and transmission electron microscopy. Fresh and deparaffinized tissue from patients with diabetes mellitus, central retinal vein occlusion, and retinoblastoma were studied. Scanning electron microscopy revealed extensive peripheral anterior synechia formation and flattening and effacement of the anterior iridic surface by a confluent fibrovascular membrane. New vessels on the anterior iris uniformly were hidden beneath a clinically inapparent, superficial layer of myofibroblasts, ie, fibroblastic cells with smooth muscle differentiation. Myofibroblasts may provide the motive force for synechial closure and ectropion iridis in neovascular glaucoma.",

author = "Thomas John and Sassani, {Joseph W.} and Eagle, {Ralph C.}",

note = "Funding Information: Supported in part by Training Grant 5T32EY0741, National Eye Institute, National Institutes of Health and the Gretel and Eugene Ormandy and Harry and Edith H. Hubschman Teaching and Research Funds, Scheie Eye Institute.",

year = "1983",

doi = "10.1016/S0161-6420(83)34520-6",

language = "English (US)",

volume = "90",

pages = "721--728",

journal = "Ophthalmology",

issn = "0161-6420",

publisher = "Elsevier Inc.",

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T1 - The Myofibroblastic Component of Rubeosis Iridis

AU - John, Thomas

AU - Sassani, Joseph W.

AU - Eagle, Ralph C.

N1 - Funding Information: Supported in part by Training Grant 5T32EY0741, National Eye Institute, National Institutes of Health and the Gretel and Eugene Ormandy and Harry and Edith H. Hubschman Teaching and Research Funds, Scheie Eye Institute.

PY - 1983

Y1 - 1983

N2 - Nineteen blind eyes enucleated for painful angle closure-glaucoma secondary to iris neovascularization (rubeosis iridis) were examined by scanning electron microscopy and correlative light and transmission electron microscopy. Fresh and deparaffinized tissue from patients with diabetes mellitus, central retinal vein occlusion, and retinoblastoma were studied. Scanning electron microscopy revealed extensive peripheral anterior synechia formation and flattening and effacement of the anterior iridic surface by a confluent fibrovascular membrane. New vessels on the anterior iris uniformly were hidden beneath a clinically inapparent, superficial layer of myofibroblasts, ie, fibroblastic cells with smooth muscle differentiation. Myofibroblasts may provide the motive force for synechial closure and ectropion iridis in neovascular glaucoma.

AB - Nineteen blind eyes enucleated for painful angle closure-glaucoma secondary to iris neovascularization (rubeosis iridis) were examined by scanning electron microscopy and correlative light and transmission electron microscopy. Fresh and deparaffinized tissue from patients with diabetes mellitus, central retinal vein occlusion, and retinoblastoma were studied. Scanning electron microscopy revealed extensive peripheral anterior synechia formation and flattening and effacement of the anterior iridic surface by a confluent fibrovascular membrane. New vessels on the anterior iris uniformly were hidden beneath a clinically inapparent, superficial layer of myofibroblasts, ie, fibroblastic cells with smooth muscle differentiation. Myofibroblasts may provide the motive force for synechial closure and ectropion iridis in neovascular glaucoma.

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DO - 10.1016/S0161-6420(83)34520-6

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JO - Ophthalmology

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The Myofibroblastic Component of Rubeosis Iridis

Abstract

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