TY - JOUR
T1 - The myogenic transcriptional network
AU - Yokoyama, Shigetoshi
AU - Asahara, Hiroshi
N1 - Funding Information:
We thank all members of the Asahara laboratory for their critical discussions and reading of the manuscript. This work was supported by a Grant-in-Aid for Scientific Research (MEXT), Health and Labour Science Research Grants.
PY - 2011/6
Y1 - 2011/6
N2 - Myogenesis has been a leading model for elucidating the molecular mechanisms that underlie tissue differentiation and development since the discovery of MyoD. During myogenesis, the fate of myogenic precursor cells is first determined by Pax3/Pax7. This is followed by regulation of the myogenic differentiation program by muscle regulatory factors (Myf5, MyoD, Myog, and Mrf4) to form muscle tissues. Recent studies have uncovered a detailed myogenic program that involves the RP58 (Zfp238)-dependent regulatory network, which is critical for repressing the expression of inhibitor of DNA binding (Id) proteins. These novel findings contribute to a comprehensive understanding of the muscle differentiation transcriptional program.
AB - Myogenesis has been a leading model for elucidating the molecular mechanisms that underlie tissue differentiation and development since the discovery of MyoD. During myogenesis, the fate of myogenic precursor cells is first determined by Pax3/Pax7. This is followed by regulation of the myogenic differentiation program by muscle regulatory factors (Myf5, MyoD, Myog, and Mrf4) to form muscle tissues. Recent studies have uncovered a detailed myogenic program that involves the RP58 (Zfp238)-dependent regulatory network, which is critical for repressing the expression of inhibitor of DNA binding (Id) proteins. These novel findings contribute to a comprehensive understanding of the muscle differentiation transcriptional program.
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U2 - 10.1007/s00018-011-0629-2
DO - 10.1007/s00018-011-0629-2
M3 - Review article
C2 - 21318263
AN - SCOPUS:79958227091
SN - 1420-682X
VL - 68
SP - 1843
EP - 1849
JO - Cellular and Molecular Life Sciences
JF - Cellular and Molecular Life Sciences
IS - 11
ER -