The origin and development of nonlymphoid tissue CD103+ DCs

Florent Ginhoux, Kang Liu, Julie Helft, Milena Bogunovic, Melanie Greter, Daigo Hashimoto, Jeremy Price, Na Yin, Jonathan Bromberg, Sergio A. Lira, E. Richard Stanley, Michel Nussenzweig, Miriam Merad

Research output: Contribution to journalArticlepeer-review

597 Scopus citations


CD103+ dendritic cells (DCs) in nonlymphoid tissues are specialized in the cross-presentation of cell-associated antigens. However, little is known about the mechanisms that regulate the development of these cells. We show that two populations of CD11c+MHCII+ cells separated on the basis of CD103 and CD11b expression coexist in most nonlymphoid tissues with the exception of the lamina propria. CD103+ DCs are related to lymphoid organ CD8+ DCs in that they are derived exclusively from pre-DCs under the control of fms-like tyrosine kinase 3 (Flt3) ligand, inhibitor of DNA protein 2 (Id2), and IFN regulatory protein 8 (IRF8). In contrast, lamina propria CD103+ DCs express CD11b and develop independently of Id2 and IRF8. The other population of CD11c +MHCII+ cells in tissues, which is CD103-CD11b +, is heterogenous and depends on both Flt3 and MCSF-R. Our results reveal that nonlymphoid tissue CD103+ DCs and lymphoid organ CD8 + DCs derive from the same precursor and follow a related differentiation program.

Original languageEnglish (US)
Pages (from-to)3115-3130
Number of pages16
JournalJournal of Experimental Medicine
Issue number13
StatePublished - Dec 21 2009

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology


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