The overlooked and undertreated perils of premature ovarian insufficiency

Samantha F. Butts

doi:10.3949/ccjm.92gr.25056

The overlooked and undertreated perils of premature ovarian insufficiency

Samantha F. Butts

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Premature ovarian insufficiency (POI) is loss of ovarian function before age 40. Genetic, autoimmune, and iatrogenic causes are well defined, but 90% of cases are idiopathic. POI prevalence is estimated to be between 3% and 4%, with many cases undiagnosed or untreated. Affected individuals experience prolonged estrogen deficiency unless hormone therapy is instituted to restore physiologic levels. Untreated POI is associated with multiple health risks, including premature death due to cardiovascular disease.

Original language	English (US)
Pages (from-to)	475-482
Number of pages	8
Journal	Cleveland Clinic Journal of Medicine
Volume	92
Issue number	8
DOIs	https://doi.org/10.3949/ccjm.92gr.25056
State	Published - Aug 1 2025

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

General Medicine

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10.3949/ccjm.92gr.25056

Cite this

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abstract = "Premature ovarian insufficiency (POI) is loss of ovarian function before age 40. Genetic, autoimmune, and iatrogenic causes are well defined, but 90\% of cases are idiopathic. POI prevalence is estimated to be between 3\% and 4\%, with many cases undiagnosed or untreated. Affected individuals experience prolonged estrogen deficiency unless hormone therapy is instituted to restore physiologic levels. Untreated POI is associated with multiple health risks, including premature death due to cardiovascular disease.",

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AB - Premature ovarian insufficiency (POI) is loss of ovarian function before age 40. Genetic, autoimmune, and iatrogenic causes are well defined, but 90% of cases are idiopathic. POI prevalence is estimated to be between 3% and 4%, with many cases undiagnosed or untreated. Affected individuals experience prolonged estrogen deficiency unless hormone therapy is instituted to restore physiologic levels. Untreated POI is associated with multiple health risks, including premature death due to cardiovascular disease.

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The overlooked and undertreated perils of premature ovarian insufficiency

Abstract

UN SDGs

All Science Journal Classification (ASJC) codes

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