TY - JOUR
T1 - The overlooked and undertreated perils of premature ovarian insufficiency
AU - Butts, Samantha F.
N1 - Publisher Copyright:
Copyright © 2025 The Cleveland Clinic Foundation. All Rights Reserved.
PY - 2025/8/1
Y1 - 2025/8/1
N2 - Premature ovarian insufficiency (POI) is loss of ovarian function before age 40. Genetic, autoimmune, and iatrogenic causes are well defined, but 90% of cases are idiopathic. POI prevalence is estimated to be between 3% and 4%, with many cases undiagnosed or untreated. Affected individuals experience prolonged estrogen deficiency unless hormone therapy is instituted to restore physiologic levels. Untreated POI is associated with multiple health risks, including premature death due to cardiovascular disease.
AB - Premature ovarian insufficiency (POI) is loss of ovarian function before age 40. Genetic, autoimmune, and iatrogenic causes are well defined, but 90% of cases are idiopathic. POI prevalence is estimated to be between 3% and 4%, with many cases undiagnosed or untreated. Affected individuals experience prolonged estrogen deficiency unless hormone therapy is instituted to restore physiologic levels. Untreated POI is associated with multiple health risks, including premature death due to cardiovascular disease.
UR - https://www.scopus.com/pages/publications/105012917185
UR - https://www.scopus.com/pages/publications/105012917185#tab=citedBy
U2 - 10.3949/ccjm.92gr.25056
DO - 10.3949/ccjm.92gr.25056
M3 - Review article
C2 - 40750321
AN - SCOPUS:105012917185
SN - 0891-1150
VL - 92
SP - 475
EP - 482
JO - Cleveland Clinic journal of medicine
JF - Cleveland Clinic journal of medicine
IS - 8
ER -
