The Pancreas and Vitamin B12 Absorption

Graham H. Jeffries

Research output: Contribution to journalEditorialpeer-review

1 Scopus citations


The intestinal absorption of physiologic amounts of vitamin B12 — about 1 μg daily — depends on a complex sequence of events in the gastrointestinal tract. Major steps in this sequence are the secretion of intrinsic factor (IF) (a glycoprotein with a molecular weight of 60,000) by gastric parietal cells, the formation of intrinsic-factor-vitamin B12 complex (IF-B12) in the intestinal lumen, the binding of IF-B12 by specific “receptors” on the microvilli of distal small-bowel epithelial cells, and the subsequent transfer of vitamin B12 across the epithelium.1,2 Each step in this normal process may be.

Original languageEnglish (US)
Pages (from-to)666-667
Number of pages2
JournalNew England Journal of Medicine
Issue number12
StatePublished - Mar 25 1971

All Science Journal Classification (ASJC) codes

  • General Medicine


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