The paradoxical effects of vitamin D on type 1 mediated immunity

Margherita T. Cantorna; Sanhong Yu; Danny Bruce

doi:10.1016/j.mam.2008.04.004

The paradoxical effects of vitamin D on type 1 mediated immunity

Margherita T. Cantorna
, Sanhong Yu
, Danny Bruce

Research output: Contribution to journal › Review article › peer-review

122 Scopus citations

Abstract

Low vitamin D status is associated with an increased risk of Th1 mediated autoimmune diseases like inflammatory bowel disease. 1,25(OH)₂D₃ treatments have been shown to suppress Th1 mediated immunity and protect animals from experimental autoimmunity. Th1 mediated immunity is important for clearance of a number of different infectious diseases. For tuberculosis 1,25(OH)₂D₃ treatment is associated with decreased Th1 mediated immunity but increased bactericidal activity. Systemic candidiasis is unaffected by 1,25(OH)₂D₃ treatment. The seemingly paradoxical effects of 1,25(OH)₂D₃ and vitamin D on Th1 mediated autoimmunity versus infectious immunity point to a broad array of vitamin D targets in the immune system. The interplay of these vitamin D targets and their impact on the host-immune response then dictate the outcome.

Original language	English (US)
Pages (from-to)	369-375
Number of pages	7
Journal	Molecular Aspects of Medicine
Volume	29
Issue number	6
DOIs	https://doi.org/10.1016/j.mam.2008.04.004
State	Published - Dec 2008

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Clinical Biochemistry

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10.1016/j.mam.2008.04.004

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title = "The paradoxical effects of vitamin D on type 1 mediated immunity",

abstract = "Low vitamin D status is associated with an increased risk of Th1 mediated autoimmune diseases like inflammatory bowel disease. 1,25(OH)2D3 treatments have been shown to suppress Th1 mediated immunity and protect animals from experimental autoimmunity. Th1 mediated immunity is important for clearance of a number of different infectious diseases. For tuberculosis 1,25(OH)2D3 treatment is associated with decreased Th1 mediated immunity but increased bactericidal activity. Systemic candidiasis is unaffected by 1,25(OH)2D3 treatment. The seemingly paradoxical effects of 1,25(OH)2D3 and vitamin D on Th1 mediated autoimmunity versus infectious immunity point to a broad array of vitamin D targets in the immune system. The interplay of these vitamin D targets and their impact on the host-immune response then dictate the outcome.",

author = "Cantorna, \{Margherita T.\} and Sanhong Yu and Danny Bruce",

note = "Funding Information: Grant support: This work was supported by National Institutes of Health Grant \#R01 DK070781 to MTC. ",

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T1 - The paradoxical effects of vitamin D on type 1 mediated immunity

AU - Cantorna, Margherita T.

AU - Yu, Sanhong

AU - Bruce, Danny

N1 - Funding Information: Grant support: This work was supported by National Institutes of Health Grant #R01 DK070781 to MTC.

PY - 2008/12

Y1 - 2008/12

N2 - Low vitamin D status is associated with an increased risk of Th1 mediated autoimmune diseases like inflammatory bowel disease. 1,25(OH)2D3 treatments have been shown to suppress Th1 mediated immunity and protect animals from experimental autoimmunity. Th1 mediated immunity is important for clearance of a number of different infectious diseases. For tuberculosis 1,25(OH)2D3 treatment is associated with decreased Th1 mediated immunity but increased bactericidal activity. Systemic candidiasis is unaffected by 1,25(OH)2D3 treatment. The seemingly paradoxical effects of 1,25(OH)2D3 and vitamin D on Th1 mediated autoimmunity versus infectious immunity point to a broad array of vitamin D targets in the immune system. The interplay of these vitamin D targets and their impact on the host-immune response then dictate the outcome.

AB - Low vitamin D status is associated with an increased risk of Th1 mediated autoimmune diseases like inflammatory bowel disease. 1,25(OH)2D3 treatments have been shown to suppress Th1 mediated immunity and protect animals from experimental autoimmunity. Th1 mediated immunity is important for clearance of a number of different infectious diseases. For tuberculosis 1,25(OH)2D3 treatment is associated with decreased Th1 mediated immunity but increased bactericidal activity. Systemic candidiasis is unaffected by 1,25(OH)2D3 treatment. The seemingly paradoxical effects of 1,25(OH)2D3 and vitamin D on Th1 mediated autoimmunity versus infectious immunity point to a broad array of vitamin D targets in the immune system. The interplay of these vitamin D targets and their impact on the host-immune response then dictate the outcome.

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DO - 10.1016/j.mam.2008.04.004

M3 - Review article

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EP - 375

JO - Molecular Aspects of Medicine

JF - Molecular Aspects of Medicine

IS - 6

ER -

The paradoxical effects of vitamin D on type 1 mediated immunity

Abstract

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