TY - JOUR
T1 - The Pharmacokinetics and Pharmacology of Oral Diltiazem in Normal Volunteers
AU - KINNEY, EVLIN L.
AU - MOSKOWITZ, RALPH M.
AU - ZELIS, ROBERT
PY - 1981
Y1 - 1981
N2 - Abstract: Oral diltiazem is being used increasingly in the treatment of Prinzmetal's angina. This study investigated the pharmacokinetics, electrocardiographic effects, and blood pressure response of normal male volunteers to various single oral doses of diltiazem. Doses selected were 30, 60, 90, and 120 mg. Thirteen subjects received 30 mg. 12 subjects received 60 mg, 10 subjects received 90 mg, diltiazem, and four subjects received 120 mg diltiazem AUCs for the 60, 90, and 120 mg doses were 565, 984, and 1258 ng/ml · hr, respectively. The values for t½, β, and tmax were similar after each dosing. 1981 American College of Clinical Pharmacology
AB - Abstract: Oral diltiazem is being used increasingly in the treatment of Prinzmetal's angina. This study investigated the pharmacokinetics, electrocardiographic effects, and blood pressure response of normal male volunteers to various single oral doses of diltiazem. Doses selected were 30, 60, 90, and 120 mg. Thirteen subjects received 30 mg. 12 subjects received 60 mg, 10 subjects received 90 mg, diltiazem, and four subjects received 120 mg diltiazem AUCs for the 60, 90, and 120 mg doses were 565, 984, and 1258 ng/ml · hr, respectively. The values for t½, β, and tmax were similar after each dosing. 1981 American College of Clinical Pharmacology
UR - http://www.scopus.com/inward/record.url?scp=0019786721&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019786721&partnerID=8YFLogxK
U2 - 10.1002/j.1552-4604.1981.tb01778.x
DO - 10.1002/j.1552-4604.1981.tb01778.x
M3 - Article
C2 - 7276227
AN - SCOPUS:0019786721
SN - 0091-2700
VL - 21
SP - 337
EP - 342
JO - The Journal of Clinical Pharmacology
JF - The Journal of Clinical Pharmacology
IS - 8-9
ER -