The pill questionnaire in a nondemented Parkinson's disease population

William Reginold, Melissa J. Armstrong, Sarah Duff-Canning, Anthony Lang, David Tang-Wai, Susan Fox, Brandon Rothberg, Cindy Zadikoff, Nancy Kennedy, David Gill, Paul Eslinger, Mark Mapstone, Kelvin Chou, Carol Persad, Irene Litvan, Benjamin Mast, Connie Marras

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


We assessed the Pill Questionnaire as a screen for mild cognitive impairment in nondemented Parkinson's disease patients. The relationship between ability to remember medications for Parkinson's disease in the Pill Questionnaire, mild cognitive impairment, and deficits on neuropsychological tests performed 2-3 weeks later blind to Pill Questionnaire results was assessed in movement disorders clinic patients. In 109 subjects, inaccurate medication reporting on the Pill Questionnaire was associated with lower scores on the Montreal Cognitive Assessment, Scales for Outcomes in Parkinson's Disease-Cognition and with deficits in memory, attention, executive function-inhibitory control, processing speed, visuospatial function, and language. Inaccurate medication reporting was also associated with an adjusted odds ratio of 2.4 (95% CI, 0.91-5.88; P = .06) for mild cognitive impairment, with a specificity of 80% and sensitivity of 41%. The Pill Questionnaire is neither sensitive nor specific enough to be used as the sole screening or diagnostic tool for mild cognitive impairment. However, inaccurate medication reporting is associated with deficits spanning many cognitive domains and should alert a clinician to a higher likelihood of cognitive impairment.

Original languageEnglish (US)
Pages (from-to)1308-1311
Number of pages4
JournalMovement Disorders
Issue number10
StatePublished - Sep 1 2012

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology


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