TY - JOUR
T1 - The primary physiological roles of autoinducer 2 in escherichia coli is chemotaxis and biofilm formation
AU - Song, Sooyeon
AU - Wood, Thomas K.
N1 - Funding Information:
Acknowledgments: This work was supported by funds derived from the Biotechnology Endowed Professorship at the Pennsylvania State University.
Funding Information:
Funding: This research was funded by a National Research Foundation of Korea (NRF) grant from the Korean government (No. NRF-2020R1F1A1072397).
Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/2
Y1 - 2021/2
N2 - Autoinducer 2 (AI-2) is a ubiquitous metabolite but, instead of acting as a “universal signal,” relatively few phenotypes have been associated with it, and many scientists believe AI-2 is often a metabolic byproduct rather than a signal. Here, the aim is to present evidence that AI-2 influences both biofilm formation and motility (swarming and chemotaxis), using Escherichia coli as the model system, to establish AI-2 as a true signal with an important physiological role in this bacterium. In addition, AI-2 signaling is compared to the other primary signal of E. coli, indole, and it is shown that they have opposite effects on biofilm formation and virulence.
AB - Autoinducer 2 (AI-2) is a ubiquitous metabolite but, instead of acting as a “universal signal,” relatively few phenotypes have been associated with it, and many scientists believe AI-2 is often a metabolic byproduct rather than a signal. Here, the aim is to present evidence that AI-2 influences both biofilm formation and motility (swarming and chemotaxis), using Escherichia coli as the model system, to establish AI-2 as a true signal with an important physiological role in this bacterium. In addition, AI-2 signaling is compared to the other primary signal of E. coli, indole, and it is shown that they have opposite effects on biofilm formation and virulence.
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U2 - 10.3390/microorganisms9020386
DO - 10.3390/microorganisms9020386
M3 - Article
C2 - 33672862
AN - SCOPUS:85100723358
SN - 2076-2607
VL - 9
SP - 1
EP - 6
JO - Microorganisms
JF - Microorganisms
IS - 2
M1 - 386
ER -