The proenkephalin gene (PENK) and opioid dependence

David E. Comings; Hezekiah Blake; George Dietz; Radhika Gade-Andavolu; Richard S. Legro; Gerard Saucier; Patrick Johnson; Ray Verde; James P. MacMurray

doi:10.1097/00001756-199904060-00042

The proenkephalin gene (PENK) and opioid dependence

David E. Comings, Hezekiah Blake, George Dietz, Radhika Gade-Andavolu, Richard S. Legro, Gerard Saucier, Patrick Johnson, Ray Verde, James P. MacMurray

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

WE tested the hypothesis that the alleles at the (CA)n repeat of the proenkephalin gene (PENK) might be associated with opioid addiction in 31 non-Hispanic Caucasian subjects with opioid dependence (heroin), 89 ethnically matched subjects with substance dependence other than opioid dependence and 132 controls. Among the subjects with opioid dependence, 66% carried the ≥ 81 bp allele compared with 40% of subjects with other types of substance abuse (χ² = 11.31, p < 0.004) and 49% of controls (X² = 6.0, p < 0.015). These results are consistent with a role of the PENK gene in opioid dependence.

Original language	English (US)
Pages (from-to)	1133-1135
Number of pages	3
Journal	Neuroreport
Volume	10
Issue number	5
DOIs	https://doi.org/10.1097/00001756-199904060-00042
State	Published - Apr 6 1999

All Science Journal Classification (ASJC) codes

General Neuroscience

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/00001756-199904060-00042

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abstract = "WE tested the hypothesis that the alleles at the (CA)n repeat of the proenkephalin gene (PENK) might be associated with opioid addiction in 31 non-Hispanic Caucasian subjects with opioid dependence (heroin), 89 ethnically matched subjects with substance dependence other than opioid dependence and 132 controls. Among the subjects with opioid dependence, 66% carried the ≥ 81 bp allele compared with 40% of subjects with other types of substance abuse (χ2 = 11.31, p < 0.004) and 49% of controls (X2 = 6.0, p < 0.015). These results are consistent with a role of the PENK gene in opioid dependence.",

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AU - Comings, David E.

AU - Blake, Hezekiah

AU - Dietz, George

AU - Gade-Andavolu, Radhika

AU - Legro, Richard S.

AU - Saucier, Gerard

AU - Johnson, Patrick

AU - Verde, Ray

AU - MacMurray, James P.

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AB - WE tested the hypothesis that the alleles at the (CA)n repeat of the proenkephalin gene (PENK) might be associated with opioid addiction in 31 non-Hispanic Caucasian subjects with opioid dependence (heroin), 89 ethnically matched subjects with substance dependence other than opioid dependence and 132 controls. Among the subjects with opioid dependence, 66% carried the ≥ 81 bp allele compared with 40% of subjects with other types of substance abuse (χ2 = 11.31, p < 0.004) and 49% of controls (X2 = 6.0, p < 0.015). These results are consistent with a role of the PENK gene in opioid dependence.

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The proenkephalin gene (PENK) and opioid dependence

Abstract

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