The prognostic utility of ICH-score in anticoagulant related intracerebral hemorrhage

Aristeidis H. Katsanos, Christos Krogias, Vasileios Arsenios Lioutas, Nitin Goyal, Ramin Zand, Vijay K. Sharma, Panayiotis Varelas, Konark Malhotra, Maurizio Paciaroni, Aboubakar Sharaf, Jason Chang, Theodore Karapanayiotides, Odysseas Kargiotis, Alexandra Pappa, Jeffrey Mai, Argyrios Tsantes, Efstathios Boviatsis, Vaia Lambadiari, Ashkan Shoamanesh, Panayiotis D. MitsiasMagdy H. Selim, Andrei V. Alexandrov, Georgios Tsivgoulis

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Although intracerebral hemorrhage (ICH) score is used to provide an estimate on the probability of mortality following spontaneous ICH of any cause, its utility has not been exclusively tested in ICH patients with history of treatment with vitamin K antagonists (VKAs) or non-vitamin K oral anticoagulants (NOACs). The aim of the present report is to investigate the utility of ICH score for mortality prognostication of VKA-ICH and NOAC-ICH patients. We used receiver operating characteristic curve analyses to estimate the accuracy parameters for the different values of ICH score in the prognosis of mortality within 30-days after the onset of NOAC-ICH or VKA-ICH. We analyzed data from 108 NOAC-ICH and 241 VKA-ICH patients (median age 76 years, 58% males, median NIHSS score 11 points, median ICH-score 2 points). ICH score of 4 points was uncovered to be the most favorable threshold for the prediction of 30-day mortality both after NOAC-ICH (sensitivity: 57.7%, specificity: 98.8%) or VKA-ICH (sensitivity: 42.1%, specificity: 92.6%). However, comparison of the areas under the curve (AUC) suggested a cumulatively higher (p = .001) predictive value of ICH-score in the prognostication of 30-day mortality after ICH related to the use of NOACs (AUC: 0.92, 95%CI: 0.86–0.98) compared to the ICH related to the use of VKAs (AUC: 0.77, 95%CI: 0.70–0.83). In conclusion, ICH score seems to have an adequate predictive utility in the prognostication of 30-day mortality following an ICH related to the use of oral anticoagulants, with better yield in ICH cases associated with the use of NOACs.

Original languageEnglish (US)
Article number116628
JournalJournal of the neurological sciences
StatePublished - Feb 15 2020

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology


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