TY - JOUR
T1 - The prognostic value of serum concentrations of progesterone, estradiol, and luteinizing hormone during superovulation with and without adjunctive leuprolide therapy
AU - Dodson, W. C.
AU - Olive, D. L.
AU - Hughes, C. L.
AU - Haney, A. F.
N1 - Funding Information:
Received August 7, 1992; revised and accepted February 10, 1993. * Supported in part by TAP Pharmaceuticals, North Chicago, Illinois. t Reprint requests: William C. Dodson, M.D., Department of Obstetrics and Gynecology, Milton S. Hershey Medical Center, Post Office Box 850, Hershey, Pennsylvania 17033. :j: Department of Obstetrics and Gynecology, Pennsylvania State University. §Department of Obstetrics and Gynecology, Yale University. II Department of Obstetrics and Gynecology, Duke University.
PY - 1993
Y1 - 1993
N2 - Objective: To determine the predictive value of preovulatory serum concentrations of P, E2, and LH for pregnancy achieved with IUI after superovulation with and without adjunctive leuprolide acetate (LA) therapy. Design: Randomized, crossover study of superovulation with and without LA therapy. Setting: Infertility clinic. Patients: Subfertile patients referred for superovulation and IUI. Main Outcome Measures: Preovulatory serum concentrations of P, E2, and LH on the day of hCG administration; pregnancy. Results: Preovulatory serum concentrations of P, E2, and LH had equivalent predictive value for pregnancy during cycles stimulated without LA therapy. No single parameter was particularly useful in clinical decision making. Threshold P concentrations proposed in other studies as useful in predicting pregnancy did not correlate with cycle fecundity. The predictive value of preovulatory concentrations of P during superovulation with adjunctive LA therapy was significantly worse than P concentrations during superovulation without LA therapy. Conclusions: Preovulatory serum P, E2, and LH concentrations in superovulation and IUI are not helpful in determining prognosis for pregnancy. The relative utility of predictive parameters may vary for different treatment regimens.
AB - Objective: To determine the predictive value of preovulatory serum concentrations of P, E2, and LH for pregnancy achieved with IUI after superovulation with and without adjunctive leuprolide acetate (LA) therapy. Design: Randomized, crossover study of superovulation with and without LA therapy. Setting: Infertility clinic. Patients: Subfertile patients referred for superovulation and IUI. Main Outcome Measures: Preovulatory serum concentrations of P, E2, and LH on the day of hCG administration; pregnancy. Results: Preovulatory serum concentrations of P, E2, and LH had equivalent predictive value for pregnancy during cycles stimulated without LA therapy. No single parameter was particularly useful in clinical decision making. Threshold P concentrations proposed in other studies as useful in predicting pregnancy did not correlate with cycle fecundity. The predictive value of preovulatory concentrations of P during superovulation with adjunctive LA therapy was significantly worse than P concentrations during superovulation without LA therapy. Conclusions: Preovulatory serum P, E2, and LH concentrations in superovulation and IUI are not helpful in determining prognosis for pregnancy. The relative utility of predictive parameters may vary for different treatment regimens.
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U2 - 10.1016/s0015-0282(16)55972-x
DO - 10.1016/s0015-0282(16)55972-x
M3 - Article
C2 - 8495761
AN - SCOPUS:0027217717
SN - 0015-0282
VL - 59
SP - 1174
EP - 1178
JO - Fertility and sterility
JF - Fertility and sterility
IS - 6
ER -