The proofreading 3′ → 5′ exonuclease activity of DNA polymerases: A kinetic barrier to translesion DNA synthesis

Keyphrases

• DNA Polymerase 100%
• DNA Lesions 100%
• Translesion Synthesis 100%
• Kinetic Barrier 100%
• Exonuclease Activity 100%
• 3′-5′ Exonuclease Activity 100%
• Exonuclease 60%
• Alkylation 40%
• Polymerase 20%
• Genome Stability 20%
• Cytotoxicity 20%
• Polymerase Activity 20%
• DNA Damage 20%
• Klenow Polymerase 20%
• Proofreading Activity 20%
• Endogenous DNA 20%
• Abasic Site 20%
• Mispair 20%
• Oxidative Lesions 20%
• DNA Substrates 20%
• Downstream Consequences 20%
• First Line of Defence 20%
• DNA Polymerase Activity 20%

Biochemistry, Genetics and Molecular Biology

• DNA Synthesis 100%
• DNA Polymerase 100%
• Exonuclease 100%
• DNA Damage 54%
• Polymerase 27%
• Alkylation 18%
• Dynamics 9%
• Cytotoxicity 9%
• Genetic Stability 9%