TY - JOUR
T1 - The Race Is On
T2 - Human Embryonic Stem Cell Research Goes Global
AU - DeRouen, Mindy C.
AU - McCormick, Jennifer B.
AU - Owen-Smith, Jason
AU - Scott, Christopher Thomas
N1 - Funding Information:
Acknowledgements MCD and JBMc contributed equally. JBMc was supported by an NSF grant (SBE 0949708) and NIH National Center for Research Resources (UL1 RR024150-4). J.O.-S was supported by NSF grants (SBE-0949708 and SES-0545634) CTS is supported by the Stanford Center for Biomedical Ethics and the Stanford Institute for Stem Cell Biology and Regenerative Medicine. The authors thank Molly Havard, Brittany Kimball, Katherine Nowakow-ski, Leona Han, and Jenny Ostergren for their valuable assistance with the manuscript.
PY - 2012/12
Y1 - 2012/12
N2 - More nations are joining the human embryonic stem cell (hESC) "race" by aggressively publishing in the peer-reviewed journals. Here we present data on the international use and distribution of hESC using a dataset taken from the primary research literature. We extracted these papers from a comprehensive dataset of articles using hESC and human induced pluripotent stem cells (hiPSC). We find that the rate of publication by US-based authors is slowing in comparison to international labs, and then declines over the final year of the period 2008-2010. Non-US authors published more frequently and at a significantly higher rate, significantly increasing the number of their papers. In addition, international labs use a more diverse set of hESC lines and Obama-era additions are used more in non-US locations. Even considering the flood of new lines in the US and abroad, we see that researchers continue to rely on a few lines derived before the turn of the century. These data suggest "embargo" effects from restrictive policies on the US stem cell field. Over time, non-US labs have freely used lines on the US registries, while federally funded US scientists have been limited to using those lines approved by the NIH.
AB - More nations are joining the human embryonic stem cell (hESC) "race" by aggressively publishing in the peer-reviewed journals. Here we present data on the international use and distribution of hESC using a dataset taken from the primary research literature. We extracted these papers from a comprehensive dataset of articles using hESC and human induced pluripotent stem cells (hiPSC). We find that the rate of publication by US-based authors is slowing in comparison to international labs, and then declines over the final year of the period 2008-2010. Non-US authors published more frequently and at a significantly higher rate, significantly increasing the number of their papers. In addition, international labs use a more diverse set of hESC lines and Obama-era additions are used more in non-US locations. Even considering the flood of new lines in the US and abroad, we see that researchers continue to rely on a few lines derived before the turn of the century. These data suggest "embargo" effects from restrictive policies on the US stem cell field. Over time, non-US labs have freely used lines on the US registries, while federally funded US scientists have been limited to using those lines approved by the NIH.
UR - http://www.scopus.com/inward/record.url?scp=84870354964&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84870354964&partnerID=8YFLogxK
U2 - 10.1007/s12015-012-9391-6
DO - 10.1007/s12015-012-9391-6
M3 - Article
C2 - 22715049
AN - SCOPUS:84870354964
SN - 1550-8943
VL - 8
SP - 1043
EP - 1047
JO - Stem Cell Reviews and Reports
JF - Stem Cell Reviews and Reports
IS - 4
ER -
