Abstract
Tyrosine hydroxylation, measured in situ in superior cervical ganglia from neonatal rats, is increased two-fold by the addition of carbachol. This increase occurs within one hour and is not due to the synthesis of new enzyme protein, nor to a direct effect of carbachol on the enzyme. The stimulation is blocked by atropine, but not by hexamethonium. This stimulation represents the first report of a receptor-mediated short-term action on this rate-limiting enzyme.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1058-1062 |
| Number of pages | 5 |
| Journal | Biochemical and Biophysical Research Communications |
| Volume | 86 |
| Issue number | 4 |
| DOIs | |
| State | Published - Feb 28 1979 |
All Science Journal Classification (ASJC) codes
- Biophysics
- Biochemistry
- Molecular Biology
- Cell Biology
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