The relation between the effect of a subhypnotic dose of thiopental on claw pain threshold in rats and adrenalin, noradrenalin and dopamine levels

Mehmet Aksoy, Ali Ahiskalioglu, Ilker Ince, Mine Celik, Aysenur Dostbil, Ufuk Kuyrukluyildiz, Durdu Altuner, Nezahat Kurt, Halis Suleyman

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Thiopental sodium (TPS) needs to be applied together with adrenalin in order to establish its analgesic effect in general anesthesia. We aimed to investigate the effect of TPS on the claw pain threshold in rats and evaluated its relationship with endogenous adrenalin (ADR), noradrenalin (NDR), and dopamine (DOP) levels. Intact and adrenalectomized rats were used in the experiment. Intact animals were divided into the following groups: 15 mg/kg TPS (TS), 0.3 mg/kg ADR+15 mg/kg TPS (ATS) and 0.3 mg/kg ADR alone (ADR). Adrenalectomized animals were divided into the following groups: 15 mg/kg TPS (A-TS), 0.3 mg/kg ADR+15 mg/kg TPS (A-ATS) and 0.3 mg/kg ADR alone (A-ADR). Claw pain threshold and blood ADR, NDR, and DOP levels were measured. The TS group’s claw pain threshold was found low. However, the claw pain thresholds of the ATS and ADR groups increased significantly. In the A-TS group, the pain threshold decreased compared with normal, and in the A-ATS and A-ADR groups, the pain threshold increased. TPS reduced the blood ADR levels in intact rats; however, no significant changes were observed in the NDR and DOP levels. #TPS provides hyperalgesia by reducing the production of ADR in rats. The present study shows that to achieve analgesic activity, TPS needs to be applied together with ADR.

Original languageEnglish (US)
Pages (from-to)391-396
Number of pages6
JournalExperimental Animals
Volume64
Issue number4
DOIs
StatePublished - Oct 23 2015

All Science Journal Classification (ASJC) codes

  • Animal Science and Zoology
  • General Biochemistry, Genetics and Molecular Biology
  • General Veterinary

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