TY - JOUR
T1 - The relationship between calcium intake and pregnancy-induced hypertension
T2 - Up-to-date evidence
AU - Belizán, JoséM M.
AU - Villar, José
AU - Repke, John
PY - 1988/1/1
Y1 - 1988/1/1
N2 - In 1980 we pointed to a relationship between calcium intake and pregnancy-induced hypertension. The original epidemiologic observations showed an inverse association between calcium intake and incidence of eclampsia after adjusting by several confounding factors. A series of recent randomized clinical trials have demonstrated a reduction in blood pressure with calcium supplementation in animals, in healthy and mildly hypertensive subjects, and in pregnant women. It is hypothesized that parathyroid hormone plays a role since it is affected by calcium intake and can partially regulate the concentration of free cytosolic ionized calcium, thus triggering smooth muscle contraction. Randomized clinical trials showing a reduction in the incidence of pregnancy-induced hypertension with calcium supplementation have not as yet been published. However, preliminary observations appear to support this hypothsis.
AB - In 1980 we pointed to a relationship between calcium intake and pregnancy-induced hypertension. The original epidemiologic observations showed an inverse association between calcium intake and incidence of eclampsia after adjusting by several confounding factors. A series of recent randomized clinical trials have demonstrated a reduction in blood pressure with calcium supplementation in animals, in healthy and mildly hypertensive subjects, and in pregnant women. It is hypothesized that parathyroid hormone plays a role since it is affected by calcium intake and can partially regulate the concentration of free cytosolic ionized calcium, thus triggering smooth muscle contraction. Randomized clinical trials showing a reduction in the incidence of pregnancy-induced hypertension with calcium supplementation have not as yet been published. However, preliminary observations appear to support this hypothsis.
UR - http://www.scopus.com/inward/record.url?scp=0023894588&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023894588&partnerID=8YFLogxK
U2 - 10.1016/0002-9378(88)90091-9
DO - 10.1016/0002-9378(88)90091-9
M3 - Article
C2 - 3284363
AN - SCOPUS:0023894588
SN - 0002-9378
VL - 158
SP - 898
EP - 902
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
IS - 4
ER -