The requirement for ferric in the initiation of lipid peroxidation by chelated ferrous iron

John R. Bucher; Ming Tien; Steven D. Aust

doi:10.1016/0006-291X(83)91366-9

The requirement for ferric in the initiation of lipid peroxidation by chelated ferrous iron

John R. Bucher, Ming Tien, Steven D. Aust

Biochemistry & Molecular Biology

Research output: Contribution to journal › Article › peer-review

229 Scopus citations

Abstract

When certain ferrous chelates are added to lipid, peroxidation of the lipid occurs following a short lag. This suggests that a product of ferrous autoxidation is required to initiate lipid peroxidation. This autoxidation product is apparently ferric iron, rather than the oxygen radicals which also result from ferrous autoxidation. Studies with oxy-radical scavengers and catalase suggest that O₂^• H₂O₂, or the ·OH are not involved in the initiation reactions, therefore, we propose that a ferrous-dioxygen-ferric chelate complex may be the initiating species.

Original language	English (US)
Pages (from-to)	777-784
Number of pages	8
Journal	Biochemical and Biophysical Research Communications
Volume	111
Issue number	3
DOIs	https://doi.org/10.1016/0006-291X(83)91366-9
State	Published - Mar 29 1983

All Science Journal Classification (ASJC) codes

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/0006-291X(83)91366-9

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title = "The requirement for ferric in the initiation of lipid peroxidation by chelated ferrous iron",

abstract = "When certain ferrous chelates are added to lipid, peroxidation of the lipid occurs following a short lag. This suggests that a product of ferrous autoxidation is required to initiate lipid peroxidation. This autoxidation product is apparently ferric iron, rather than the oxygen radicals which also result from ferrous autoxidation. Studies with oxy-radical scavengers and catalase suggest that O2• H2O2, or the ·OH are not involved in the initiation reactions, therefore, we propose that a ferrous-dioxygen-ferric chelate complex may be the initiating species.",

author = "Bucher, {John R.} and Ming Tien and Aust, {Steven D.}",

note = "Funding Information: preparation We would of this like manuscript. to thank Mrs. Supported Cathy in M. part Custer by a for grant secretarial from the assistance National Science in the Foundation, PCM-7915328, and a National Research Service Award (John R. Bucher) from the U.S. Public Health Service. Michigan Agricultural Experiment Station Journal Article Number 10710.",

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AU - Bucher, John R.

AU - Tien, Ming

AU - Aust, Steven D.

N1 - Funding Information: preparation We would of this like manuscript. to thank Mrs. Supported Cathy in M. part Custer by a for grant secretarial from the assistance National Science in the Foundation, PCM-7915328, and a National Research Service Award (John R. Bucher) from the U.S. Public Health Service. Michigan Agricultural Experiment Station Journal Article Number 10710.

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Y1 - 1983/3/29

N2 - When certain ferrous chelates are added to lipid, peroxidation of the lipid occurs following a short lag. This suggests that a product of ferrous autoxidation is required to initiate lipid peroxidation. This autoxidation product is apparently ferric iron, rather than the oxygen radicals which also result from ferrous autoxidation. Studies with oxy-radical scavengers and catalase suggest that O2• H2O2, or the ·OH are not involved in the initiation reactions, therefore, we propose that a ferrous-dioxygen-ferric chelate complex may be the initiating species.

AB - When certain ferrous chelates are added to lipid, peroxidation of the lipid occurs following a short lag. This suggests that a product of ferrous autoxidation is required to initiate lipid peroxidation. This autoxidation product is apparently ferric iron, rather than the oxygen radicals which also result from ferrous autoxidation. Studies with oxy-radical scavengers and catalase suggest that O2• H2O2, or the ·OH are not involved in the initiation reactions, therefore, we propose that a ferrous-dioxygen-ferric chelate complex may be the initiating species.

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The requirement for ferric in the initiation of lipid peroxidation by chelated ferrous iron

Abstract

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