The role of glutathione in aging and cancer

John P. Richie

doi:10.1016/0531-5565(92)90015-R

The role of glutathione in aging and cancer

John P. Richie

Research output: Contribution to journal › Article › peer-review

77 Scopus citations

Abstract

The incidence and mortality rates from most cancers increase exponentially with age. It is likely that this aging phenomenon is partially due to specific changes that occur in the host resulting in an increased susceptibility to neoplasia. Our hypothesis is that one such host factor is a deficiency in GSH, based on the importance of this compound in the detoxification of a wide variety of exogenous and endogenous carcinogens and free radicals, as well as in the maintenance of immune function.

Original language	English (US)
Pages (from-to)	615-626
Number of pages	12
Journal	Experimental Gerontology
Volume	27
Issue number	5-6
DOIs	https://doi.org/10.1016/0531-5565(92)90015-R
State	Published - 1992

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Biochemistry
Aging
Molecular Biology
Genetics
Endocrinology
Cell Biology

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10.1016/0531-5565(92)90015-R

Cite this

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title = "The role of glutathione in aging and cancer",

abstract = "The incidence and mortality rates from most cancers increase exponentially with age. It is likely that this aging phenomenon is partially due to specific changes that occur in the host resulting in an increased susceptibility to neoplasia. Our hypothesis is that one such host factor is a deficiency in GSH, based on the importance of this compound in the detoxification of a wide variety of exogenous and endogenous carcinogens and free radicals, as well as in the maintenance of immune function.",

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AB - The incidence and mortality rates from most cancers increase exponentially with age. It is likely that this aging phenomenon is partially due to specific changes that occur in the host resulting in an increased susceptibility to neoplasia. Our hypothesis is that one such host factor is a deficiency in GSH, based on the importance of this compound in the detoxification of a wide variety of exogenous and endogenous carcinogens and free radicals, as well as in the maintenance of immune function.

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UR - https://www.scopus.com/pages/publications/0026737356#tab=citedBy

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JO - Experimental Gerontology

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ER -

The role of glutathione in aging and cancer

Abstract

UN SDGs

All Science Journal Classification (ASJC) codes

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