The role of kupffer cell oxidant production in early ethanol-induced liver disease

Michael D. Wheeler, Hiroshi Kono, Ming Yin, Mikio Nakagami, Takehiko Uesugi, Gavin E. Arteel, Erwin Gäbele, Ivan Rusyn, Shunhei Yamashina, Matthias Froh, Yuki Adachi, Yuji Iimuro, Blair U. Bradford, Olivia M. Smutney, Henry D. Connor, Ronald P. Mason, Sanna M. Goyert, Jeff M. Peters, Frank J. Gonzalez, R. Jude SamulskiRonald G. Thurman

Research output: Contribution to journalArticlepeer-review

227 Scopus citations


Considerable evidence for a role of Kupffer cells in alcoholic liver disease has accumulated and they have recently been shown to be a predominant source of free radicals. Several approaches including pharmacological agents, knockout mice, and viral gene transfer have been used to fill critical gaps in understanding key mechanisms by which Kupffer cell activation, oxidant formation, and cytokine production lead to liver damage and subsequent pathogenesis. This review highlights new data in support of the hypothesis that Kupffer cells play a pivotal role in hepatotoxicity due to ethanol by producing oxidants via NADPH oxidase.

Original languageEnglish (US)
Pages (from-to)1544-1549
Number of pages6
JournalFree Radical Biology and Medicine
Issue number12
StatePublished - Dec 15 2001

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physiology (medical)


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