The role of kupffer cell oxidant production in early ethanol-induced liver disease

Michael D. Wheeler; Hiroshi Kono; Ming Yin; Mikio Nakagami; Takehiko Uesugi; Gavin E. Arteel; Erwin Gäbele; Ivan Rusyn; Shunhei Yamashina; Matthias Froh; Yuki Adachi; Yuji Iimuro; Blair U. Bradford; Olivia M. Smutney; Henry D. Connor; Ronald P. Mason; Sanna M. Goyert; Jeff M. Peters; Frank J. Gonzalez; R. Jude Samulski; Ronald G. Thurman

doi:10.1016/S0891-5849(01)00748-1

The role of kupffer cell oxidant production in early ethanol-induced liver disease

Michael D. Wheeler, Hiroshi Kono, Ming Yin, Mikio Nakagami, Takehiko Uesugi, Gavin E. Arteel, Erwin Gäbele, Ivan Rusyn, Shunhei Yamashina, Matthias Froh, Yuki Adachi, Yuji Iimuro, Blair U. Bradford, Olivia M. Smutney, Henry D. Connor, Ronald P. Mason, Sanna M. Goyert, Jeff M. Peters, Frank J. Gonzalez, R. Jude SamulskiRonald G. Thurman

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235 Scopus citations

Abstract

Considerable evidence for a role of Kupffer cells in alcoholic liver disease has accumulated and they have recently been shown to be a predominant source of free radicals. Several approaches including pharmacological agents, knockout mice, and viral gene transfer have been used to fill critical gaps in understanding key mechanisms by which Kupffer cell activation, oxidant formation, and cytokine production lead to liver damage and subsequent pathogenesis. This review highlights new data in support of the hypothesis that Kupffer cells play a pivotal role in hepatotoxicity due to ethanol by producing oxidants via NADPH oxidase.

Original language	English (US)
Pages (from-to)	1544-1549
Number of pages	6
Journal	Free Radical Biology and Medicine
Volume	31
Issue number	12
DOIs	https://doi.org/10.1016/S0891-5849(01)00748-1
State	Published - Dec 15 2001

All Science Journal Classification (ASJC) codes

Biochemistry
Physiology (medical)

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Wheeler, M. D., Kono, H., Yin, M., Nakagami, M., Uesugi, T., Arteel, G. E., Gäbele, E., Rusyn, I., Yamashina, S., Froh, M., Adachi, Y., Iimuro, Y., Bradford, B. U., Smutney, O. M., Connor, H. D., Mason, R. P., Goyert, S. M., Peters, J. M., Gonzalez, F. J., ... Thurman, R. G. (2001). The role of kupffer cell oxidant production in early ethanol-induced liver disease. Free Radical Biology and Medicine, 31(12), 1544-1549. https://doi.org/10.1016/S0891-5849(01)00748-1

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title = "The role of kupffer cell oxidant production in early ethanol-induced liver disease",

abstract = "Considerable evidence for a role of Kupffer cells in alcoholic liver disease has accumulated and they have recently been shown to be a predominant source of free radicals. Several approaches including pharmacological agents, knockout mice, and viral gene transfer have been used to fill critical gaps in understanding key mechanisms by which Kupffer cell activation, oxidant formation, and cytokine production lead to liver damage and subsequent pathogenesis. This review highlights new data in support of the hypothesis that Kupffer cells play a pivotal role in hepatotoxicity due to ethanol by producing oxidants via NADPH oxidase.",

author = "Wheeler, {Michael D.} and Hiroshi Kono and Ming Yin and Mikio Nakagami and Takehiko Uesugi and Arteel, {Gavin E.} and Erwin G{\"a}bele and Ivan Rusyn and Shunhei Yamashina and Matthias Froh and Yuki Adachi and Yuji Iimuro and Bradford, {Blair U.} and Smutney, {Olivia M.} and Connor, {Henry D.} and Mason, {Ronald P.} and Goyert, {Sanna M.} and Peters, {Jeff M.} and Gonzalez, {Frank J.} and Samulski, {R. Jude} and Thurman, {Ronald G.}",

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doi = "10.1016/S0891-5849(01)00748-1",

language = "English (US)",

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Wheeler, MD, Kono, H, Yin, M, Nakagami, M, Uesugi, T, Arteel, GE, Gäbele, E, Rusyn, I, Yamashina, S, Froh, M, Adachi, Y, Iimuro, Y, Bradford, BU, Smutney, OM, Connor, HD, Mason, RP, Goyert, SM, Peters, JM, Gonzalez, FJ, Samulski, RJ & Thurman, RG 2001, 'The role of kupffer cell oxidant production in early ethanol-induced liver disease', Free Radical Biology and Medicine, vol. 31, no. 12, pp. 1544-1549. https://doi.org/10.1016/S0891-5849(01)00748-1

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T1 - The role of kupffer cell oxidant production in early ethanol-induced liver disease

AU - Wheeler, Michael D.

AU - Kono, Hiroshi

AU - Yin, Ming

AU - Nakagami, Mikio

AU - Uesugi, Takehiko

AU - Arteel, Gavin E.

AU - Gäbele, Erwin

AU - Rusyn, Ivan

AU - Yamashina, Shunhei

AU - Froh, Matthias

AU - Adachi, Yuki

AU - Iimuro, Yuji

AU - Bradford, Blair U.

AU - Smutney, Olivia M.

AU - Connor, Henry D.

AU - Mason, Ronald P.

AU - Goyert, Sanna M.

AU - Peters, Jeff M.

AU - Gonzalez, Frank J.

AU - Samulski, R. Jude

AU - Thurman, Ronald G.

PY - 2001/12/15

Y1 - 2001/12/15

N2 - Considerable evidence for a role of Kupffer cells in alcoholic liver disease has accumulated and they have recently been shown to be a predominant source of free radicals. Several approaches including pharmacological agents, knockout mice, and viral gene transfer have been used to fill critical gaps in understanding key mechanisms by which Kupffer cell activation, oxidant formation, and cytokine production lead to liver damage and subsequent pathogenesis. This review highlights new data in support of the hypothesis that Kupffer cells play a pivotal role in hepatotoxicity due to ethanol by producing oxidants via NADPH oxidase.

AB - Considerable evidence for a role of Kupffer cells in alcoholic liver disease has accumulated and they have recently been shown to be a predominant source of free radicals. Several approaches including pharmacological agents, knockout mice, and viral gene transfer have been used to fill critical gaps in understanding key mechanisms by which Kupffer cell activation, oxidant formation, and cytokine production lead to liver damage and subsequent pathogenesis. This review highlights new data in support of the hypothesis that Kupffer cells play a pivotal role in hepatotoxicity due to ethanol by producing oxidants via NADPH oxidase.

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The role of kupffer cell oxidant production in early ethanol-induced liver disease

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