The role of peripheral venous distension reflex in regulating hemodynamics: mini review

Takuto Hamaoka; Lawrence Sinoway; Jian Cui

doi:10.1016/j.autneu.2024.103217

The role of peripheral venous distension reflex in regulating hemodynamics: mini review

Takuto Hamaoka, Lawrence Sinoway, Jian Cui

Research output: Contribution to journal › Short survey › peer-review

Abstract

Significant volume is pooled in veins in humans and the amount is dramatically altered by various physiological stresses and diseases. Several animal and human studies demonstrated that limb venous distension evoked significant increases in blood pressure and sympathetic nerve activity (venous distension reflex, VDR). VDR has attracted much attention because of its potential to explain the still unknown mechanism of autonomic dysfunction in several diseases, which would lead to a new treatment approach. This mini review discusses accumulated evidence of VDR at this point and what should be investigated in the future to apply the current understanding of VDR in clinical practice.

Original language	English (US)
Article number	103217
Journal	Autonomic Neuroscience: Basic and Clinical
Volume	256
DOIs	https://doi.org/10.1016/j.autneu.2024.103217
State	Published - Dec 2024

All Science Journal Classification (ASJC) codes

Endocrine and Autonomic Systems
Clinical Neurology
Cellular and Molecular Neuroscience

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.autneu.2024.103217

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title = "The role of peripheral venous distension reflex in regulating hemodynamics: mini review",

abstract = "Significant volume is pooled in veins in humans and the amount is dramatically altered by various physiological stresses and diseases. Several animal and human studies demonstrated that limb venous distension evoked significant increases in blood pressure and sympathetic nerve activity (venous distension reflex, VDR). VDR has attracted much attention because of its potential to explain the still unknown mechanism of autonomic dysfunction in several diseases, which would lead to a new treatment approach. This mini review discusses accumulated evidence of VDR at this point and what should be investigated in the future to apply the current understanding of VDR in clinical practice.",

author = "Takuto Hamaoka and Lawrence Sinoway and Jian Cui",

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language = "English (US)",

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AU - Hamaoka, Takuto

AU - Sinoway, Lawrence

AU - Cui, Jian

PY - 2024/12

Y1 - 2024/12

N2 - Significant volume is pooled in veins in humans and the amount is dramatically altered by various physiological stresses and diseases. Several animal and human studies demonstrated that limb venous distension evoked significant increases in blood pressure and sympathetic nerve activity (venous distension reflex, VDR). VDR has attracted much attention because of its potential to explain the still unknown mechanism of autonomic dysfunction in several diseases, which would lead to a new treatment approach. This mini review discusses accumulated evidence of VDR at this point and what should be investigated in the future to apply the current understanding of VDR in clinical practice.

AB - Significant volume is pooled in veins in humans and the amount is dramatically altered by various physiological stresses and diseases. Several animal and human studies demonstrated that limb venous distension evoked significant increases in blood pressure and sympathetic nerve activity (venous distension reflex, VDR). VDR has attracted much attention because of its potential to explain the still unknown mechanism of autonomic dysfunction in several diseases, which would lead to a new treatment approach. This mini review discusses accumulated evidence of VDR at this point and what should be investigated in the future to apply the current understanding of VDR in clinical practice.

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SN - 1566-0702

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JO - Autonomic Neuroscience: Basic and Clinical

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The role of peripheral venous distension reflex in regulating hemodynamics: mini review

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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