The role of store-operated calcium channel in chronic inflammation

Shengyu Yang; Wei Chiao Chang

The role of store-operated calcium channel in chronic inflammation

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Calcium is an important second arymessenger that regulates a variety of physiological functions, including cell proliferation, enzyme metabolism, gene expression and apoptosis. In non-excitable cells such as T lymphocytes, hepatocytes, mast cells, endothelia and cancer cells, the predominant mechanism for calcium(Ca₂₊) entry is through store-operated Ca₂₊ channels (SOCs),which are activated by the emptying of intracellular Ca₂₊ stores. Here, we review some of the proposed gating mechanisms of store-operated Ca₂₊ channel and the functional implications of SOCs in the regulation of pro-inflammatory signals and tumor progression.

Original language	English (US)
Title of host publication	Chronic Inflammation
Subtitle of host publication	Causes, Treatment Options and Role in Disease
Publisher	Nova Science Publishers, Inc.
Pages	1-18
Number of pages	18
ISBN (Print)	9781628080940
State	Published - Dec 1 2013

All Science Journal Classification (ASJC) codes

General Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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abstract = "Calcium is an important second arymessenger that regulates a variety of physiological functions, including cell proliferation, enzyme metabolism, gene expression and apoptosis. In non-excitable cells such as T lymphocytes, hepatocytes, mast cells, endothelia and cancer cells, the predominant mechanism for calcium(Ca2+) entry is through store-operated Ca2+ channels (SOCs),which are activated by the emptying of intracellular Ca2+ stores. Here, we review some of the proposed gating mechanisms of store-operated Ca2+ channel and the functional implications of SOCs in the regulation of pro-inflammatory signals and tumor progression.",

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ER -

The role of store-operated calcium channel in chronic inflammation

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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