The role of store-operated calcium channel in chronic inflammation

Shengyu Yang, Wei Chiao Chang

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Calcium is an important second arymessenger that regulates a variety of physiological functions, including cell proliferation, enzyme metabolism, gene expression and apoptosis. In non-excitable cells such as T lymphocytes, hepatocytes, mast cells, endothelia and cancer cells, the predominant mechanism for calcium(Ca2+) entry is through store-operated Ca2+ channels (SOCs),which are activated by the emptying of intracellular Ca2+ stores. Here, we review some of the proposed gating mechanisms of store-operated Ca2+ channel and the functional implications of SOCs in the regulation of pro-inflammatory signals and tumor progression.

Original languageEnglish (US)
Title of host publicationChronic Inflammation
Subtitle of host publicationCauses, Treatment Options and Role in Disease
PublisherNova Science Publishers, Inc.
Number of pages18
ISBN (Print)9781628080940
StatePublished - Dec 1 2013

All Science Journal Classification (ASJC) codes

  • General Medicine


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