TY - JOUR
T1 - The role of temperament and social support in depressive symptoms
T2 - A twin study of mid-aged women
AU - Yuh, Jongil
AU - Neiderhiser, Jenae M.
AU - Spotts, Erica L.
AU - Pedersen, Nancy L.
AU - Lichtenstein, Paul
AU - Hansson, Kjell
AU - Cederblad, Marianne
AU - Elthammer, Olle
AU - Reiss, David
N1 - Funding Information:
This report is part of the Twin Mothers project, supported by Grant R01MH54610 (Principal Investigator, D. Reiss) from the National Institute of Mental Health.
Funding Information:
This report is part of the Twin Mothers project, supported by NIMH Grant R01MH54610. The NIMH had no further role in research method and this publication.
PY - 2008/2
Y1 - 2008/2
N2 - Background: Although research has found that temperament and social support are associated with depression, these relationships have not been explored in conjunction with one another as they relate to depression using a genetically informative design. This study investigated how the association among the three constructs is mediated. Methods: The sample in this study consisted of 326 pairs of adult monozygotic and dizygotic twins drawn from the Swedish Twin Registry. Twins were mothers of adolescent from married or partnered relationships. The genetic and environmental contributions to the association were evaluated by self-reported measures of temperament, social support, and depressive symptoms. Results: Multivariate genetic model fitting revealed that a moderate portion of genetic influences were common among the three central constructs of harm avoidance, perceived social support, and depressive symptoms. Limitations: The results may not be generalizable to depressive disorders in clinical settings. The measures were self-reported from a cross-sectional study. Conclusions: The findings suggest that the heritable component may contribute to genetic influences on an individual's ability to secure social support and thus to genetic risk for depressive symptomatology in women.
AB - Background: Although research has found that temperament and social support are associated with depression, these relationships have not been explored in conjunction with one another as they relate to depression using a genetically informative design. This study investigated how the association among the three constructs is mediated. Methods: The sample in this study consisted of 326 pairs of adult monozygotic and dizygotic twins drawn from the Swedish Twin Registry. Twins were mothers of adolescent from married or partnered relationships. The genetic and environmental contributions to the association were evaluated by self-reported measures of temperament, social support, and depressive symptoms. Results: Multivariate genetic model fitting revealed that a moderate portion of genetic influences were common among the three central constructs of harm avoidance, perceived social support, and depressive symptoms. Limitations: The results may not be generalizable to depressive disorders in clinical settings. The measures were self-reported from a cross-sectional study. Conclusions: The findings suggest that the heritable component may contribute to genetic influences on an individual's ability to secure social support and thus to genetic risk for depressive symptomatology in women.
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U2 - 10.1016/j.jad.2007.05.025
DO - 10.1016/j.jad.2007.05.025
M3 - Article
C2 - 17610958
AN - SCOPUS:37349124140
SN - 0165-0327
VL - 106
SP - 99
EP - 105
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
IS - 1-2
ER -
