The role of the perioperative period in recurrence after cancer surgery

Antje Gottschalk, Sonal Sharma, Justin Ford, Marcel E. Durieux, Mohamed Tiouririne

Research output: Contribution to journalReview articlepeer-review

261 Scopus citations


A wealth of basic science data supports the hypothesis that the surgical stress response increases the likelihood of cancer dissemination and metastasis during and after cancer surgery. Anesthetic management of the cancer patient, therefore, could potentially influence long-term outcome. Preclinical data suggest that beneficial approaches might include selection of induction drugs such as propofol, minimizing the use of volatile anesthetics, and coadministration of cyclooxygenase antagonists with systemic opioids. Retrospective clinical trials suggest that the addition of regional anesthesia might decrease recurrence after cancer surgery. Other factors such as blood transfusion, temperature regulation, and statin administration may also affect long-term outcome.

Original languageEnglish (US)
Pages (from-to)1636-1643
Number of pages8
JournalAnesthesia and analgesia
Issue number6
StatePublished - Jun 2010

All Science Journal Classification (ASJC) codes

  • Anesthesiology and Pain Medicine


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