TY - JOUR
T1 - The serotonin transporter gene and startle response during nicotine deprivation
AU - Minnix, Jennifer A.
AU - Robinson, Jason D.
AU - Lam, Cho Y.
AU - Carter, Brian L.
AU - Foreman, Jennifer E.
AU - Vandenbergh, David J.
AU - Tomlinson, Gail E.
AU - Wetter, David W.
AU - Cinciripini, Paul M.
N1 - Funding Information:
Support for this research was provided by grants from NCI ( 1R21CA81649 ) and NIDA ( R01DA1182-01 ) to Paul Cinciripini as well as post-doctoral fellowships from the MD Anderson Education Program in Cancer Prevention grant (R25-CA57730) to Jennifer A. Minnix, Jason D. Robinson, and Cho Y. Lam. Nasal spray was provided by Pharmacia and Upjohn, Inc.
PY - 2011/1
Y1 - 2011/1
N2 - Affective startle probe methodology was used to examine the effects of nicotine administration and deprivation on emotional processes among individuals carrying at least one s allele versus those with the l/l genotype of the 5-Hydroxytryptamine (Serotonin) Transporter Linked Polymorphic Region, 5-HTTLPR in the promoter region of the serotonin transporter gene [solute ligand carrier family 6 member A4 (SLC6A4) or SERT]. Smokers (n=84) completed four laboratory sessions crossing deprivation (12-h deprived vs. non-deprived) with nicotine spray (nicotine vs. placebo). Participants viewed affective pictures (positive, negative, neutral) while acoustic startle probes were administered. We found that smokers with the l/l genotype showed significantly greater suppression of the startle response when provided with nicotine vs. placebo than those with the s/s or s/l genotypes. The results suggest that l/l smokers, who may have higher levels of the serotonin transporter and more rapid synaptic serotonin clearance, experience substantial reduction in activation of the defensive system when exposed to nicotine.
AB - Affective startle probe methodology was used to examine the effects of nicotine administration and deprivation on emotional processes among individuals carrying at least one s allele versus those with the l/l genotype of the 5-Hydroxytryptamine (Serotonin) Transporter Linked Polymorphic Region, 5-HTTLPR in the promoter region of the serotonin transporter gene [solute ligand carrier family 6 member A4 (SLC6A4) or SERT]. Smokers (n=84) completed four laboratory sessions crossing deprivation (12-h deprived vs. non-deprived) with nicotine spray (nicotine vs. placebo). Participants viewed affective pictures (positive, negative, neutral) while acoustic startle probes were administered. We found that smokers with the l/l genotype showed significantly greater suppression of the startle response when provided with nicotine vs. placebo than those with the s/s or s/l genotypes. The results suggest that l/l smokers, who may have higher levels of the serotonin transporter and more rapid synaptic serotonin clearance, experience substantial reduction in activation of the defensive system when exposed to nicotine.
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U2 - 10.1016/j.biopsycho.2010.09.013
DO - 10.1016/j.biopsycho.2010.09.013
M3 - Article
C2 - 20888887
AN - SCOPUS:78650417285
SN - 0301-0511
VL - 86
SP - 1
EP - 8
JO - Biological Psychology
JF - Biological Psychology
IS - 1
ER -