TY - JOUR
T1 - The serotonin transporter
T2 - Sequence variation in Macaca fascicularis and its relationship to dominance
AU - Miller-Butterworth, Cassandra M.
AU - Kaplan, Jay R.
AU - Barmada, M. Michael
AU - Manuck, Stephen B.
AU - Ferrell, Robert E.
N1 - Funding Information:
Acknowledgements The authors thank Dewayne Cairnes and Melissa Ayers for assistance with obtaining samples, Heather Brockway, Yvette Conley, Mark Kimak, Chris Kline, Elizabeth Lawrence, Nancy Petro, Marisa Winkler and the staff of the University of Pittsburgh Genomics & Proteomics Core Laboratories for their facilities and assistance with laboratory work. We also thank Bernie Devlin, Pan-ayiotis Benos and Shawn Wood for their statistical expertise. This work was supported by a National Research Service Award (# 5 F32 MH073397) to CMB from the National Institutes of Mental Health.
PY - 2007/9
Y1 - 2007/9
N2 - Specific genotypes of the rhesus monkey and human serotonin transporter gene (SERT) promoter region are associated with personality traits and serotonergic activity. However, the most commonly studied promoter polymorphism (5-HTTLPR) is monomorphic in many other monkey species. To date, no systematic search for alternative potentially functional polymorphisms across the remaining coding parts of the gene has been undertaken in other primate species, despite the crucial role SERT plays in modulating serotonergic tone. We investigated whether sequence variation in this gene is associated with social rank and serotonin metabolite (5-HIAA) differences in 524 cynomolgus macaques. Sequence variation and extent of linkage disequilibrium (LD) across the regulatory and coding regions were initially characterized in 92 macaques. The exons and promoter contained 28 polymorphisms, more than double that recorded for human SERT. In further contrast to humans, the macaque SERT showed no significant LD. Potentially functional polymorphisms were genotyped in all animals. No individual variants or haplotypes were significantly associated with social rank or 5-HIAA concentrations; however, certain serotonin transporter diplotypes may modulate acquisition of dominance status.
AB - Specific genotypes of the rhesus monkey and human serotonin transporter gene (SERT) promoter region are associated with personality traits and serotonergic activity. However, the most commonly studied promoter polymorphism (5-HTTLPR) is monomorphic in many other monkey species. To date, no systematic search for alternative potentially functional polymorphisms across the remaining coding parts of the gene has been undertaken in other primate species, despite the crucial role SERT plays in modulating serotonergic tone. We investigated whether sequence variation in this gene is associated with social rank and serotonin metabolite (5-HIAA) differences in 524 cynomolgus macaques. Sequence variation and extent of linkage disequilibrium (LD) across the regulatory and coding regions were initially characterized in 92 macaques. The exons and promoter contained 28 polymorphisms, more than double that recorded for human SERT. In further contrast to humans, the macaque SERT showed no significant LD. Potentially functional polymorphisms were genotyped in all animals. No individual variants or haplotypes were significantly associated with social rank or 5-HIAA concentrations; however, certain serotonin transporter diplotypes may modulate acquisition of dominance status.
UR - http://www.scopus.com/inward/record.url?scp=35148900967&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=35148900967&partnerID=8YFLogxK
U2 - 10.1007/s10519-007-9162-3
DO - 10.1007/s10519-007-9162-3
M3 - Article
C2 - 17605101
AN - SCOPUS:35148900967
SN - 0001-8244
VL - 37
SP - 678
EP - 696
JO - Behavior Genetics
JF - Behavior Genetics
IS - 5
ER -