Abstract
A series of 5’-0-sulfamoylated carbocyclic 2’,3’-dideoxy nucleosides was synthesized and evaluated for antitumor and anti-HIV activities. In this study, we have combined the phosphate mimicking features of the sulfamoyl group with our previously reported antiviral carbocyclic nucleoside, carbovir. In a related strategy, the sufamoyl moiety was used as a replacement for the a-phosphate of AZT-triphosphate in an analog designed to examine a membrane permeable HIV reverse transcriptase inhibitor. Some of the analogs exhibited significant in vitro anticancer activity.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2051-2060 |
| Number of pages | 10 |
| Journal | Nucleosides and Nucleotides |
| Volume | 14 |
| Issue number | 9-10 |
| DOIs | |
| State | Published - Nov 1 1995 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
All Science Journal Classification (ASJC) codes
- Biochemistry
- Genetics
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