TY - JOUR
T1 - The Tec family of tyrosine kinases in T cells, amplifiers of T cell receptor signals
AU - August, Avery
AU - Fischer, Angela
AU - Hao, Shengli
AU - Mueller, Cynthia
AU - Ragin, Melanie
N1 - Funding Information:
We apologize to all the investigators whose work could not be adequately discussed or referenced due to the lack of space. We thank Jason Mercer for critically reading this review. Work in the August lab is supported by grants from the NSF (MCB-9912383), the Johnson and Johnson Focused Giving Program, the Leukemia Research Foundation, the Life Science Consortium Innovative Biotechnology Research Fund at Penn State (all to A. August) and the NIH (R01 DK040242 to D.M. Wojchowski).
PY - 2002
Y1 - 2002
N2 - ITK and Rlk/Txk are the predominant Tec family of tyrosine kinases expressed in T cells, and are involved in T cell antigen receptor mediated activation of T cells. These kinases require prior activation of Lck, Zap-70 and PI3-kinase for efficient activation. They share major substrates with both Lck and Zap-70, however the pathways they regulate are unclear. Recent evidence suggests that these kinases may not activate unique pathways, but instead serve as amplifiers for the upstream kinases Lck and Zap-70. This review will discuss the evidence for this view.
AB - ITK and Rlk/Txk are the predominant Tec family of tyrosine kinases expressed in T cells, and are involved in T cell antigen receptor mediated activation of T cells. These kinases require prior activation of Lck, Zap-70 and PI3-kinase for efficient activation. They share major substrates with both Lck and Zap-70, however the pathways they regulate are unclear. Recent evidence suggests that these kinases may not activate unique pathways, but instead serve as amplifiers for the upstream kinases Lck and Zap-70. This review will discuss the evidence for this view.
UR - http://www.scopus.com/inward/record.url?scp=0035986609&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035986609&partnerID=8YFLogxK
U2 - 10.1016/S1357-2725(02)00068-7
DO - 10.1016/S1357-2725(02)00068-7
M3 - Short survey
C2 - 12127569
AN - SCOPUS:0035986609
SN - 1357-2725
VL - 34
SP - 1184
EP - 1189
JO - International Journal of Biochemistry and Cell Biology
JF - International Journal of Biochemistry and Cell Biology
IS - 10
ER -