TY - JOUR
T1 - The Temporal Relationship in Arterial and Venous Prostacyclin and Thromboxane Activity during 24 Hours of Intraaortic Balloon Counterpulsation in Dogs
AU - Hoover, Eddie L.
AU - Kharma, Bassam
AU - Ross, Margery
AU - Webb, Hueldine
AU - Hsu, Hwei Kang
AU - Clark, Luther
AU - Toporoff, Bruce
AU - Cunningham, Joseph N.
PY - 1988
Y1 - 1988
N2 - We studied the effects of intraaortic balloon counterpulsation (IABCP) on prostacyclin (PGI2) and thromboxane (TXB2) levels in dogs during 24 hours of 1:1 IABCP or a sham procedure in which the balloon was positioned but left deflated. The arterial PGI2 levels in the IABCP group increased from control values of 95 ± 20 pg/ml to 268 ± 95 pg/ml at 1 hour, 429 ± 95 pg/ml at 4 hours, and 1,884 ± 532 pg/ml at 24 hours. The arterial PGI2 levels were consistently higher in the IABCP group. Although the TXB2 measurements revealed no significant differences between groups, the IABCP group consistently had a higher level than the sham group. The platelet count in the control group decreased to 45% of baseline levels versus 55% for the IABCP group. We conclude that prolonged IABCP results in either net production of PGI2 or decreased degradation. The correlation between TXB2 and platelet counts is unclear and remains to be defined.
AB - We studied the effects of intraaortic balloon counterpulsation (IABCP) on prostacyclin (PGI2) and thromboxane (TXB2) levels in dogs during 24 hours of 1:1 IABCP or a sham procedure in which the balloon was positioned but left deflated. The arterial PGI2 levels in the IABCP group increased from control values of 95 ± 20 pg/ml to 268 ± 95 pg/ml at 1 hour, 429 ± 95 pg/ml at 4 hours, and 1,884 ± 532 pg/ml at 24 hours. The arterial PGI2 levels were consistently higher in the IABCP group. Although the TXB2 measurements revealed no significant differences between groups, the IABCP group consistently had a higher level than the sham group. The platelet count in the control group decreased to 45% of baseline levels versus 55% for the IABCP group. We conclude that prolonged IABCP results in either net production of PGI2 or decreased degradation. The correlation between TXB2 and platelet counts is unclear and remains to be defined.
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U2 - 10.1016/S0003-4975(10)64730-3
DO - 10.1016/S0003-4975(10)64730-3
M3 - Article
C2 - 3058060
AN - SCOPUS:0024208354
SN - 0003-4975
VL - 46
SP - 661
EP - 665
JO - Annals of Thoracic Surgery
JF - Annals of Thoracic Surgery
IS - 6
ER -